International Journal of Health Sciences and Research

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Review Article

Year: 2018 | Month: November | Volume: 8 | Issue: 11 | Pages: 270-278

Role of Interleukin-1 Beta in Orthodontics

Dr. S. Lalithapriya1, Dr. K. Rajasigamani2, Dr. V. Bhaskar3

1Ph.D Research scholar, 2Dean & HOD, 3Professor,
Department of Orthodontics & Dentofacial Orthopaedics, Rajah Muthiah Dental College & Hospital, Annamalai University, Chidambaram, Tamil Nadu, India. Pin-608002

Corresponding Author: Dr. S. Lalithapriya


The core of orthodontic treatment philosophy was to move the teeth through the bone to a favourable position thereby obtaining an aesthetically and functionally stable occlusion. The mechanical force was the therapeutic tool used by an orthodontist during orthodontic treatment. An efficient orthodontic tooth movement can be accomplished with the appropriate use of mechanics and adequate knowledge about the biological response. Interleukin-1beta, a member of cytokine family was one among the various molecules that got activated and released in response to the applied mechanical force in tissues and cells surrounding the tooth structure and plays a key role in initiating an aseptic inflammatory response which was not only a prerequisite for bone remodelling and tooth movement but also had an effect on other associated phenomenon such as pain and resorption during orthodontic tooth movement. This paper contains a brief description on the significance of Interleuin-1beta in orthodontics and an attempt had been made to understand the cross talk between the pathways leading to bone remodelling, pain, tooth movement, and root resorption as they all have inflammation as a common thread.

Key words: IL-1beta, Inflammation, OTM, EARR, pain, bone remodelling.

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