Original Research Article
Year: 2019 | Month: September | Volume: 9 | Issue: 9 | Pages: 269-274
Comparative Evaluation of Fructosamine and HbA1c as a Marker of Glycemic Control in Type 2 Diabetes: A Hospital Based Study
Dr. Jyoti Goyal1, Dr. Nibhriti Das2, Dr. Navin Kumar3, Ms. Seema Raghav4, Dr. Paramjeet Singh Bhatia5, Dr. Karunesh Prasad Singh6, Dr. Sabari Das7
1DNB, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India- 281003,
2Ex-Director of Laboratory services and Additional Dean Research and Academics, Nayati Healthcare and Research Centre, Mathura, India- 281003,
3Ph.D, Biostatistitian, Department of Biostatistics, Nayati Healthcare and Research Centre, Mathura, India-281003.
4M.Sc., Certified Diabetes Educator, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003.
5MD, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003.
6MD Physician, Department of Internal Medicine, Nayati Healthcare and Research Centre, Mathura, India-281003.
7Department of Laboratory Medicine, Nayati Healthcare and Research Centre, Mathura, India- 281003,
Corresponding Author: Dr. Jyoti Goyal
ABSTRACT
Introduction: Management of type 2 diabetes revolves around achievement of target glycemic control with the help of antidiabetic drugs or insulin. There are various markers for measurement of glyceamic control like HbA1c, Mean Blood Glucose and fructosamine levels. Though HbA1c is a well validated standard method for assessment of glycemic control but it has also got certain limitations. Fructosamine, a less explored method may be used as an alternative marker for an assessment of glycemic control in cases where HbA1c is unreliable or unavailable. The objective of this study is to compare the fructosamine levels with HbA1c in assessment of glycemic control in type 2 diabetics so as to assess the utility of fructosamine as an alternative marker for evaluation of glucose control.
Materials and Methods: This is a cross-sectional study of retrospective data collected from 48type 2 diabetic patients who attended the medical outdoor of Nayati Medicity, Mathura, Uttar Pradesh. Data was collected from January 2018 to June 2018. Data was collected in terms of age, sex, BMI, duration of diabetes, fructosamine, HBA1c and FBS levels. Level of glycemic control was assessed with HbA1c and Fructosamine and fasting blood glucose levels.
Results: Analysis of glycemic control of 48type 2 diabetic patients showed that fructosamine and HbA1C level have statistically significant correlation with each other (p value < 0.001).
Conclusion: The level of fructosamine and HbA1C are significantly correlated with each other; and hence Fructosamine can be used as an alternative biomarker for assessment of glyceamic control in type 2 diabetics especially when hba1c values are unreliable or not available.
Key words: FBS (Fasting Blood Sugar), HbA1c (Glycosylated Hemoglobin), Fructosamine, BMI (Body Mass Index), Type 2 Diabetes