Original Research Article
Year: 2019 | Month: August | Volume: 9 | Issue: 8 | Pages: 353-359
The Influence of BMI on the PSA Status of Nigerian Men Affected By Prostate Cancer
Dr. Collins Amadi1, Dr. Sarah I. Essien2
1Senior Registrar, Department of Chemical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria
2Lecturer 11, Department of Chemical Pathology, University of Uyo, Uyo, Akwa Ibom State, Nigeria
Corresponding Author: Dr. Collins Amadi
ABSTRACT
Background: Data mostly from the Caucasian population is suggestive of an inverse influence of BMI on the PSA levels. Hence, this study was instituted to examine this relationship among Nigerian men of Negroid race with prostate cancer (PCa) disease.
Materials and Methods: This descriptive cross-sectional study was conducted prospectively in a tertiary health center in Nigeria among 220 males with treatment-naïve and histologically-confirmed PCa disease. Clinical, anthropometric and laboratory variables were obtained from each study participant and analyzed using SPSS software version 21. Laboratory analytical methods were carried out under standard protocols.
Results: The majority (n = 95; 43.2%) of the study population were within 70- 79 years of age bracket. The rates of ideal weight, overweight, and obese status among the study population were 23.2% (n = 51), 55.0% (n = 121), and 21.8% (n = 48) respectively. Increasing BMI trend was associated with a significant progressive decrease in the total serum PSA levels. An inverse relationship existed between PSA and BMI among the entire study cohorts (Beta: -0.709; SE: 0.198); p < 0.001), overweight cohorts (Beta: -0.268; SE: 0.671); p = 0.003) and among the obese cohorts (Beta: -0.384; SE: 0.223; p = 0.007).
Conclusion: The study affirms the inverse association between BMI and PSA in patients with PCa disease and this inverse relationship was more pronounced among the obese cohorts. This relationship should be considered in interpreting PSA results among obese individuals with prostate cancer disease.
Key words: Nigeria; Prostate cancer; BMI; PSA.