Original Research Article
Year: 2019 | Month: July | Volume: 9 | Issue: 7 | Pages: 24-29
Correlation of Histomorphological Prognostic Factors of Invasive Breast Carcinoma-NST with ER/PR and HER2
Atul Beniwal1, Priyanka Dahiya2, Heena Shah1, Sujata R Kanetkar3, Suresh J Bhosale4
1Assistant Lecturer, Department of Pathology, Krishna Institute of Medical Sciences and Research Institute, Karad, India.
2Assistant Professor, Department of Obstetrics and Gynaecology, Kalpana Chawla Government Medical College, Karnal, India.
3Professor, Department of Pathology, Krishna Institute of Medical Sciences and research Institute, Karad, India.
4Professor, Department of Surgery, Krishna Institute of Medical Sciences and research Institute, Karad, India.
Corresponding Author: Atul Beniwal
ABSTRACT
Background: Breast carcinoma is one of the leading causes of mortality and morbidity in middle aged females. Numerous histomorphological prognostic factors including hormonal receptor status play vital role in further management of patient care. Objectives: This study was undertaken with the aims and objectives to study the correlation of tumor size, tumor grade and regional lymph node metastasis with hormone receptors(ER, PR and HER2).
Materials and methods: This is a retrospective study; all patients diagnosed with Invasive breast carcinoma-NST within June2013-Sep2015 were included. MRM specimen’s gross and microscopic finding were collected and studied.
Results: Total 141 patients were studied. Maximum numbers of patients were from 5th decade, left sided tumor was found in 61%cases. Tumor size of 2.1-5cm was found in 58.9% cases. Axillary lymph node metastasis was found in 54.6% cases. Statistically significant association of ER/PR was found with Tumor size (P 0.041) and with Axillary lymph node status (P 0.012). Statistically significant association of HER2 was found with Axillary lymph node status (P 0.049).
Conclusion: Our study shows that ER/PR and HER2 are important indicators of breast carcinoma prognosis and are positively correlated with other important prognostic factors.
Key words: Breast carcinoma, Estrogen Receptor, Progesterone Receptor, HER2, Breast