Original Research Article
Year: 2018 | Month: June | Volume: 8 | Issue: 6 | Pages: 75-80
Estimation of Salivary Cortisol Level in Oral Lichen Planus and Oral Leukoplakia Patients
Dr. Sonia Gupta1, Dr. Nitin Ahuja2
1Oral Pathologist, Jammu
2Reader, Department of Oral and Maxillofacial Pathology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, (U.P.)-201201, India.
Corresponding Author: Dr. Sonia Gupta
ABSTRACT
Introduction: - Cortisol, also known as stress hormone has been used as an indicator for the evaluation of stress.
Aims: - The aims of the present study was to determine salivary cortisol levels in patients with oral lichen planus, oral leukoplakia and normal oral mucosa and its correlation with DAS (Depression, anxiety and stress) scale.
Materials and method: - A cross-sectional study was carried out on 10 patients each of oral lichen planus, oral leukoplakia and normal oral mucosa. DAS scale was applied to each patients and morning unstimulated saliva was collected. From the sample, salivary cortisol levels were analysed using enzyme-linked immunosorbent assay method.
Results: - In the present study, depression, anxiety and stress along with salivary cortisol levels were higher in oral lichen planus as compared to oral leukoplakia and normal oral mucosa patients which were in the normal range. A positive correlation was found between salivary cortisol levels in oral lichen planus and psychological factors.
Conclusion: - DAS scale plays an important role in estimating the psychological state of the patient which can be related with the salivary cortisol level. Thus, depression, anxiety and stress play an important role in the pathogenesis of oral lichen planus.
Key words: Stress, Saliva, Lichen planus, Leukoplakia, Depression, Anxiety.