Original Research Article
Year: 2018 | Month: February | Volume: 8 | Issue: 2 | Pages: 67-72
Effect of Glycemic Status on Serum CEA and CA 19-9 Levels in Patients of Diabetes Mellitus in Northern India
Dr. Ritika Singla1, Dr. Ashutosh Goyal2, Dr. Bhawna Mahajan3, Dr. V K Gupta4
1Associate Consultant, Artemis Hospitals, Gurgaon, Haryana, India.
2Consultant, Paras Hospitals, Gurgaon, Haryana, India.
3Associate Professor, 4Director Professor,
G B Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.
Corresponding Author: Dr. Ashutosh Goyal
ABSTRACT
Cancer biomarkers can be used in early detection of several cancers as well as in detection of recurrence and following response to treatment. Glycemic status of diabetic patients can influence the serum levels of these markers even in the absence of malignancy. In the present study we aimed to investigate the effect of glycemia on the levels of two tumor markers CEA and CA 19-9. A total of 100 subjects were enrolled in the study, 50 patients of poorly controlled Diabetes Mellitus and 50 healthy controls. We measured fasting plasma glucose, HbA1c, lipid profile (total cholesterol, triglycerides and HDL cholesterol), serum CA 19-9 and serum CEA levels with an automatic analyzer in all the subjects. Fasting plasma glucose (FPG), HbA1c, serum CEA, CA 19-9 and triglycerides were significantly higher in the study group compared to controls. Serum CEA showed a significant positive correlation with FPG and HbA1c and a significant negative correlation with HDL-C levels whereas serum CA 19-9 showed a significant positive correlation only with FPG. We propose to formulate a higher cut off of CEA and CA 19-9 in diabetic subjects considering the effects of hyperglycemia, to avoid further invasive investigations.
Key words: Diabetes Mellitus; CEA; CA 19-9; Lipid Profile