Original Research Article
Year: 2018 | Month: February | Volume: 8 | Issue: 2 | Pages: 226-232
Evaluation of Interleukin-23 in Periodontal Health and Disease
Ghaida Raja Althebeti1, Fathy Mohamed Elfasakhany2, Eman Abdulsattar Talla3
1Dental Intern, Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
2Associate Professor of Medical Biochemistry and Molecular Biology, Department of Basic and Clinical Oral Sciences, Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia; Department of Medical Biochemistry, Department of Biochemistry, Faculty of Medicine, Tanta University, Egypt
3Professor of Periodontology, Department of Basic and Clinical Oral Sciences, Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia
Corresponding Author: Ghaida Raja Althebeti
ABSTRACT
Background: Periodontitis is a chronic inflammatory disease that causes tooth-supporting tissues destruction. It has been found that IL-23 is increased at sites suffering from clinical attachment loss, indicating that IL-23 may have a role in the progression of periodontitis.
Objective: This study aim was to evaluate the level of IL-23 in gingival crevicular fluid and blood in the studied groups (localized aggressive periodontitis, chronic periodontitis, gingivitis and controls) selected from Umm Al-Qura University.
Materials & Methods: Forty systemically healthy female subjects were included in this study and divided into 4 groups; 10 subjects with localized aggressive periodontitis, 10 subjects with chronic periodontitis, 10 subjects with gingivitis and 10 control subjects. Gingival crevicular fluid and blood were obtained from all subjects and evaluated using enzyme-linked immunosorbent assay (ELISA).
Results: IL-23 level was statistically significantly higher in gingival crevicular fluid and blood of chronic periodontitis group compared with the control group, gingivitis group and localized aggressive group.
Conclusion: There is a statistical significant increase in the IL-23 concentration of gingival crevicular fluid and blood in chronic periodontitis. Therefore, IL-23 may have a role in the pathogenesis of chronic periodontitis.
Key words: Gingival crevicular fluid, IL-23, Chronic periodontitis, localized aggressive periodontitis.