Original Research Article
Year: 2018 | Month: February | Volume: 8 | Issue: 2 | Pages: 7-18
Immunohistochemical Profiling of Lymphomas in Jos University Teaching Hospital, Jos
Ajetunmobi OI1, Mandong BM2, Adelusola KA3, Silas OA2
1Department of Histopathology, Federal Medical Centre, Makurdi, Benue State, Nigeria.
2Department of Histopathology, Jos University Teaching Hospital, Plateau State.
3Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University, Ile-Ife Osun State.
Corresponding Author: Ajetunmobi OI
ABSTRACT
Background: Lymphomas are a significant cause of disease burden globally. In Nigeria, lymphomas are the commonest malignancies in children, and the third commonest in adults. Effectual treatment is dependent on identification of definite lymphoma subtypes.
Objective: This study was undertaken to document the histologic and immunophenotypic subtypes of lymphomas in Jos.
Methods: All lymphomas cases, diagnosed over a period of 5 years, at the Jos University Teaching Hospital, were reviewed and classified according to their morphologic characteristics. Immunostaining with a panel of four monoclonal antibodies, was employed for classification according to cell lineage.
Results: A total of one hundred and eleven (111) histologically diagnosed lymphomas were seen during the 5 year period (2008-2012). Lymphomas were commoner in females with a male to female ratio of 0.8:1. Approximately 48.7% of cases occurred within the 36-65 years age bracket while children accounted for 17.9% of cases. Non-Hodgkin lymphomas were predominant, accounting for 89.7% of cases, while Hodgkin lymphoma made up 10.3%. Diffuse large cell and Burkitt lymphomas were the commonest histologic subtypes of non-Hodgkin lymphoma. The nodular sclerosing subtype was the commonest variant of Hodgkin lymphoma. Immunophenotypically, B cell lymphomas accounted for 77.1% of all non-Hodgkin lymphomas, T cell lymphomas were seen in 5.7% of cases, while phenotyping was inconclusive in 17.1% of cases of non Hodgkin lymphoma.
Conclusion: Immunohistochemistry is invaluable in delineating lymphoid lesions in accordance with their cell of origin, as well as determining the course of therapy.
Key words: Lymphoma, Hodgkins, Immunohistochemistry, Phenotyping.