Original Research Article
Year: 2017 | Month: February | Volume: 7 | Issue: 2 | Pages: 137-140
Evaluation of Serum 25-Hydroxyvitamin D Levels in Type 2 Diabetes Mellitus Patients
Dr. Garima Sehgal1, Dr. Jasvir Singh2, Dr. Sanjeev Kumar3
1Department of Biochemistry, Government Medical College Patiala, Punjab
2Assistant Professor, Department of Biochemistry, Government Medical College Patiala, Punjab
3Professor, Department of Internal Medicine, Rajindra Hospital Patiala, Punjab
Corresponding Author: Dr. Garima Sehgal
ABSTRACT
Background: Vitamin D plays an important role in calcium metabolism and vitamin D deficiency may be associated with a range of diseases, including cardiovascular disease and type 2 diabetes and has been associated with impaired insulin action, through direct effect of vitamin D on the β-cell function.
Aim: To evaluate serum 25 -Hydroxy vitamin D levels in type 2 diabetes mellitus patients.
Materials And Methods: The study was conducted on 45 diagnosed type 2 Diabetes mellitus patients and 25 non-diabetic age and gender matched control in the Department of Biochemistry, Government Medical College Patiala sample was collected in plain vial and serum25-hydroxy vitamin D levels were evaluated by ELISA technique and the results were statistically analysed.
Results: The Mean values of serum 25-hydroxyvitamin D levels in study group and control group were 16.31± 14.03 and 26.63 ± 16.54 respectively (Normal Value of vitamin D =30-74 ng/ml).The decrease in Vitamin D levels in study group as compared to control group shows statistically significant association(p value< 0.07) .
Conclusions: Vitamin D levels appeared to be lower in diabetes mellitus type 2 patients than in the control group. These findings may have therapeutic implications as cautious vitamin D supplementation may improve glycemic control in diabetes mellitus type 2.
Key words: Type 2 Diabetes Mellitus, 25-Hydroxy Vitamin D, Vitamin D receptors, Beta cells of Pancreas