Original Research Article
Year: 2016 | Month: November | Volume: 6 | Issue: 11 | Pages: 103-108
Inhibition of Poly(ADP-Ribose) Polymerase (PARP) Protects against Experimental Immune Complex-Induced Ovarian Failure in Mice
Elena Shepel, Nataliya Grushka, Nataliya Makogon, Tatyana Voznesenskaya, Roman Yanchii
Department of Immunophysiology, Bogomoletz Institute of Physiology, Kyiv, Ukraine.
Corresponding Author: Nataliya Grushka
ABSTRACT
The effects of PARP inhibitor, 4-hydroxyquinazoline (4-HQ), on ovarian damage were studied in mouse model of immune complex (IC) injury induced by immunization with bovine serum albumin (BSA). The BSA injections impaired the meiotic maturation of oocytes, enhanced necrosis and reduced expression of COX2, GREM1 and HAS2 genes in follicular cells. Treatment of mice with 4-HQ exerted beneficial effect on the ovarian function and oocyte quality in IC–mediated injury: improved oocyte maturation, diminished necrosis and significantly enhanced the expression of mRNA for COX2 and GREM1 in follicular cells.
Key words: Oocytes, Follicular cells, Immune complex diseases, PARP inhibitors, Mice.