Original Research Article
Year: 2014 | Month: February | Volume: 4 | Issue: 2 | Pages: 73-77
Study of Serum Acid Phosphatase Levels in Children with Malaria
Shilpa A. Pratinidhi1*, Sarita V Agarwal2*, Aparna A Sagare3*, Subhangi H Gawade3*, Sandhya V Haribhakta2**, Mamta V Hegde4*, Namrata A Ghatge3*, Manaskumar Behera4**, Dnyaneshwari P. Ghadage4***, Khyati Kalra5#
1Professor, 2Assistant Professor, 3Assistant Lecturer, 4Professor and Head, 5Assistant Professor cum Statistician,
*Department of Biochemistry,**Department of Paediatrics,***Department of Microbiology,#Department of Community Medicine,
Smt. Kashibai Navale Medical College and General Hospital, Pune- 411041 (Maharashtra), India.
Corresponding Author: Shilpa A. Pratinidhi
ABSTRACT
Objective and Study Design: This was a cross-sectional study aimed to evaluate the significance of the serum acid phosphatase (ACP) activity along with Haemoglobin and other biochemical and haematological activity in patients with malaria and non malarial normal healthy control children.
Material and Methods: This study was conducted at Smt. Kashibai Navale Medical College and General Hospital, Pune (Maharashtra), India. A total of 60 children in the age group of six months to twelve years were included in the study. They were divided into two groups. The study was carried out during the period between September 2012 and February 2013. Venous blood samples were collected from all participants. The whole blood and sera were analyzed for various haematological and biochemical parameters respectively. The statistical analysis was done by EPI Information statistical package.
Results: ACP was significantly increased (P=0.037) and Hb level (P= 0.027) was significantly decreased in malarial group as compared with the controls. There is a negative correlation (r=-.035) between ACP and Hb in malarial patients, which is statistically significant. The difference in the levels of haematological parameters namely TLC, Platelet count, MCV, MCH, MCHC. The levels of biochemical parameters namely Total Bilirubin, Unconjugated Bilirubin and Conjugated Bilirubin were statistically not significant. Similarly the mean age and gender was statistically not significant.
Conclusion: These findings suggest that the measurement of ACP can be used as a marker for malaria.
Key words: Malaria, Haemoglobin, Acid Phosphatase.