Year: 2026 | Month: March | Volume: 16 | Issue: 3 | Pages: 201-215
DOI: https://doi.org/10.52403/ijhsr.20260325
Distribution of Staphylococcus aureus from Clinical Isolates Across Spectrum of Departments and Patient Profiles - A Clinico-Epidemiologic Study in Tertiary Care Medical College of Eastern India
Sourav Pal1, Amritendu Mandal2, Ayan Goswami3, Neeladri Majumder4, Agnik Pal5
1Assistant Professor, Department of Microbiology, Santiniketan Medical College, Bolpur, West Bengal 731204
2Assistant Professor, Department of General Medicine, East West Institute of Medical Sciences and Research, Talit, Purba Barddhaman, West Bengal 713141
3Associate Professor, Department of Physiology, Maharshi Devraha Baba Autonomous State Medical College, Deoria, Uttar Pradesh 274001
4Assistant Professor, Department of Pharmacology, Santiniketan Medical College, Bolpur, West Bengal 731204
5Professor and Head, Department of Pharmacology, Santiniketan Medical College, Bolpur, West Bengal 731204
Corresponding Author: Dr. Agnik Pal
ABSTRACT
Background: The study was undertaken to find out the distribution profile of S. aureus strains including methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) in different age, sex as well as in clinical isolates from various departments of a tertiary care teaching hospital to understand the local epidemiologic pattern of the organism.
Materials and Methods: The present prospective study was carried out in a tertiary care teaching hospital where different clinical specimens (including blood, urine, pus, CSF, sputum, venous catheter tip, endotracheal tubing’s, patient associated devices and sterile body fluids like pleural fluids, synovial fluids etc.) from different departments (OPDs and wards), were studied for staphylococci.
Results: The median age of the patients was 20 years with no difference in the occurrence of S. aureus infection, MSSA or MRSA, with gender. S. aureus infection was in higher occurrence in age group 21 to 45, followed by the infants, both for MRSA and MSSA. Also in both these groups, MRSA infections were significantly more common than MSSA. Of the total S. aureus isolates, 66.5% were from cutaneous and wound infections including surgical site infections; followed by bloodstream infections, 23.3%. 63.3% of the isolates from blood samples were MRSA. Highest number of S aureus isolates was from surgery department (34.2%). However highest percentage of MRSA isolates (39.8%) were from department of pediatrics.
Conclusion: MRSA infections were more common in infants and children <5 years of age; Most common infections were cutaneous and wound infections including surgical site infections and bloodstream infections; MRSA isolates were more commonly obtained from wards and ICUs. MSSA were more common in OPD isolates. High percentage of MRSA isolated from medicine ICU and pediatric ICUs including neonatal ICUs indicates high rate of transmission of MRSA in these settings.
Key words: Methicillin-resistant staphylococcus aureus, Methicillin-sensitive staphylococcus aureus, Surgical Site Infection, Bloodstream Infection, Respiratory Tract Infection, Urinary Tract Infection