Year: 2024 | Month: August | Volume: 14 | Issue: 8 | Pages: 167-173
DOI: https://doi.org/10.52403/ijhsr.20240824
Neutrophil-Lymphocyte Ratio: Adjunct Prognostic Biomarker in Oral Squamous Cell Carcinoma (OSCC) – A Study in Delhi NCR
Mihir Sharma1, Dr Charu Agarwal2, Dr. Mukta Pujani3, Dr Varsha Chauhan4, Dr Aparna Singh5, Dr Abhishek Jaiswal6
1Final Prof MBBS Student, ESIC Medical College, Faridabad, Haryana
2MD, DNB (Pathology), MNAMS, MAMS, Associate Professor, Dept. of Pathology, ESIC Medical College, Faridabad, Haryana
3MD (Pathology), MAMS, Professor and Head, Dept. of Pathology, ESIC Medical College, Faridabad, Haryana
4MD Pathology, Associate Professor Deptt of Pathology, ESIC Medical College & Hospital, Faridabad
5MD Pathology, Assistant Professor, Deptt of Pathology, ESIC Medical College & Hospital, Faridabad
6MD Community Medicine, Assistant Professor, Deptt of Community Medicine, ESIC Medical College & Hospital, Faridabad
Corresponding Author: Dr Varsha Chauhan
ABSTRACT
Background: Inflammation is now recognized as the seventh hallmark of cancer. Neutrophil-lymphocyte ratio holds promise as an adjunct biomarker in various cancers.
Materials and methods: 32 biopsy-confirmed OSCC patients and 32 healthy controls were enrolled in this prospective case-control study and venous blood samples were obtained and CBC reports were thus used for analysis of various haematological parameters such as NLR, using t-test, and Mann-Whitney U test using STATA.
Results: The median NLR was found to be raised in OSCC patients as compared to healthy controls and the difference was found to be statistically significant ((Median:3.83(2.31-5.56) vs. 2.14(1.80-2.66), p=0.0006)
Conclusions : NLR can be used as a useful tool for clinicians as an adjunct biomarker for the prognostication and potentially help in the diagnosis of OSCC in screening. Future studies should include a larger sample size and should be longitudinal in nature as well as should explore differences in NLR in benign, premalignant and malignant cases.
Key words: Neutrophil-lymphocyte ratio, biomarker, oral squamous cell carcinoma, cancer, hematological