Year: 2024 | Month: January | Volume: 14 | Issue: 1 | Pages: 18-29
DOI: https://doi.org/10.52403/ijhsr.20240103
Serum Levels of Immunoglobulin M, Interleukin-10 and C-Reactive Protein in Adults with Sickle Cell Disorder in Nigerian Population
Baridi P. Nyienakuna1, Eugene E. Akujuru2, Olufemi G. Omitola3, Anthonia A. Okerengwo1
1Department of Haematology, Blood Transfusion and Immunology, Faculty of Basic Clinal Science,
2Department of Biomedical Technology, School of Science Laboratory Technology,
3Department of Oral Pathology & Oral Biology, Faculty of Dentistry University of Port Harcourt, Port Harcourt, Nigeria.
Corresponding Author: Eugene E. Akujuru
ABSTRACT
Background: Evidence suggests that sickle cell disorder (SCD) is associated with a chronic inflammatory state. This study was aimed at evaluating the levels of inflammatory and immunological parameters (immunoglobulin (Ig) M, interleukin (IL)-10, and C-reactive protein (CRP)) in Nigerian patients with SCD and comparing them with those in age- and sex- matched healthy subjects.
Methods: A total of 90 participants were recruited into this study, 45 of whom were SCD subjects from the clinic of the Department of Haematology, University of Port Harcourt Teaching Hospital (UPTH), Port Harcourt, while the other 45 were healthy subjects from the Blood Donor Centre of the same institution. Serum levels of IgM, IL-10 and CRP were assayed using commercial Enzyme Linked Immunosorbent Assay (ELISA) kits.
Results: The mean serum concentrations of IgM and CRP were statistically significantly (p<0.05) lower in the SCD subjects compared to the control subjects. On the other hand, IL-10 was statistically significantly (p<0.05) higher in the SCD group than the control subjects. Also, the levels of IgM, IL-10 and CRP were not different between the male and female groups as well as among the different age groups in both the SCD and control subjects.
Conclusion: The results suggest that inflammatory mediators may be altered and may play a role in the pathogenesis of sickle cell disorder.
Key words: sickle cell disorder; immunoglobulin M; interleukin 10; C-reactive protein