Year: 2024 | Month: October | Volume: 14 | Issue: 10 | Pages: 492-497
DOI: https://doi.org/10.52403/ijhsr.20241053
The Role of Oxidative Stress in Gestational Diabetes Mellitus
Birjis Fatma1, Dr. Abid Nadeem Nomani2, Dr. Sheeba Nuzhat Khan3, Prof. Suboohi Mustafa4
1MS Scholar D/O Niswan-Wa-Qabalat, Ajmal Khan Tibbiya College & Hospital, Aligarh Muslim University, Aligarh, UP, India.
2Research Officer, Central Research Unit, Ribandar, Goa, CCRUM Ministry of AYUSH Govt of India
3Assistant Professor D/O Kulliyat, Ajmal Khan Tibbiya College & Hospital, Aligarh Muslim University, Aligarh, UP, India
4Professor D/O Niswan-Wa-Qabalat, Ajmal Khan Tibbiya College & Hospital, Aligarh Muslim University, Aligarh, UP, India.
Corresponding Author: Birjis Fatma
ABSTRACT
The most typical pregnancy-related medical problem is gestational diabetes mellitus. The hormones released during pregnancy, particularly human placental lactogen, estrogen, and progesterone, are responsible for this illness because they can hinder the body's ability to metabolize carbohydrates and tolerate insulin. Hyperglycemia during pregnancy is caused by the action of these hormones. Maternal plasma and placental tissues have higher levels of oxidative stress in GDM patients. And antioxidants are reduced in placental tissue and maternal blood. Consequently, a decrease in antioxidant levels may cause rise in the oxidative stress and result in poor pregnancy outcomes. In GDM-affected women, antioxidant, probiotics and nutritional supplements have been used to lower indicators of oxidative stress.
Key words: oxidative stress, Gestational diabetes mellitus, antioxidant