Original Research Article
Year: 2023 | Month: August | Volume: 13 | Issue: 8 | Pages: 79-83
DOI: https://doi.org/10.52403/ijhsr.20230812
Association of Histomorphological Prognostic Factors of Invasive Breast Carcinoma - NST with Axillary Lymph Node
Atul Beniwal1, Priyanka Dahiya2, Indira Mawlia3
1Assistant professor, Department of pathology, Kalpana Chawla Government Medical College, Karnal
2Associate professor, Department of obstetrics and gynaecology, Kalpana Chawla Government Medical College, Karnal
3Assistant professor, Department of anesthesia, Maulana Azad Medical College, New Delhi, Delhi
Corresponding Author: Atul Beniwal
ABSTRACT
Background: Breast carcinoma is one of the leading malignancy in women. Surgical MRM specimen histology and prognostic factors play important role in management of the patient and need to be examined in detail to help clinician for better treatment options.
Materials and methods: Two-year study of MRM specimens which were IBC-NST were included. Gross and microscopic prognostic factors were studied and analysed with axillary lymph node involvement, using Bivariate analysis by Chi Square using SPSS.
Results: Total 141 cases were studied. Maximum (59%) cases had tumor size between 2.1-5cm. According to modified RB tumor grading system, 48% had Grade-III and 44% had Grade-II tumor. Tumor emboli were positive in 60.7% and tumor necrosis was positive in 47% cases. Retracted nipple was seen in 38% of cases. Both ER/PR were found positive in 43%cases and both ER/PR were found negative in 52% cases, HER2 was negative in 72%cases. Axillary lymph nodes were not involved in 45.4% cases, while 19.1%, 14.9% and 10.6% cases were positive for 1-3, 4-7 and 8-10 axillary lymph node involvement respectively. Statistically significant association (p< 0.05) of axillary lymph node was found with Tumor emboli, HER2 status, ER/PR status, Tumor size, Nipple Areola Complex and Overlying Skin. Borderline association (p nearing 0.05) was found with Skin involvement by tumor and Tumor grade.
Conclusion: Axillary lymph node status is an important prognostic factor in breast carcinoma and it is found associated with other important histomorphological prognostic factors which needs to be evaluated thoroughly for better post-operative patient care.
Key words: Breast carcinoma, Axillary lymph node, histomorphological prognostic factors,