Original Research Article
Year: 2023 | Month: August | Volume: 13 | Issue: 8 | Pages: 1-7
DOI: https://doi.org/10.52403/ijhsr.20230801
Histomorphologic Prognostic Factors in Invasive Breast Carcinoma-NST Affecting Loco-Regional Recurrence
Atul Beniwal1, Priyanka Dahiya2, Indira Mawlia3
1Assistant Professor, Department of pathology, Kalpana Chawla Government Medical College, Karnal
2Associate Professor, Department of obstetrics and gynaecology, Kalpana Chawla Government Medical College, Karnal
3Assistant Professor, Department of Anesthesia, Maulana Azad Medical College, New Delhi
Corresponding Author: Atul Beniwal
ABSTRACT
Background: Breast carcinoma is one of the important and leading cause of mortality and morbidity in women. Locally advanced breast cancer constitutes more than 50-70% of the patients presenting for treatment in India.1 Due to heterogeneous nature of the disease multi disciplinary approach is required to treat the disease. Numerous histopathological prognostic factors have been identified which helps in exploring the nature of disease and finding the probability of loco-regional recurrence.
Material: In current study all post operative MRM specimens 8 years retrospective ad 2 years prospective were included which came out to be IBC-NST. Detailed gross and histomorphological prognostics factors were studied and documented. Patients were followed up and were examined for loco regional recurrence. Statistical Bivariate analysis by Chi Square was done for all demographic and histomorphological factors with recurrence.
Result: Total 141 specimens were obtained and patients were followed up. Out of 141 cases 11 (8%) had recurrence. Minimum time for recurrence was 2 months and maximum was 34 months with mean of 14.4 months.
Statistically significant association (p<0.05) of recurrence was found with positive surgical margin, positive axillary lymph node and ER/PR status.
Borderline significant association (p nearing 0.05 but not less than 0.05) of recurrence was found with consistency of lump, tumor fixity to underlying tissue, tumor size, tumor emboli, multicentricity, overlying skin change, tumor grade and HER2.
No association was found with lump location, tumor necrosis, nipple-areola complex change, skin involvement by tumor.
Conclusion: The association of recurrence with histomorphological prognostic factors help us in assessing the outcome of the disease. It aids in calculating the probability of recurrence by studying the prognostic factors in MRM specimen. Clinician can assess the risk of recurrence and can offer better treatment to the patient.
Key words: Breast carcinoma, histomorphologic factors, prognostic factors, recurrence.