Original Research Article
Year: 2023 | Month: July | Volume: 13 | Issue: 7 | Pages: 244-252
DOI: https://doi.org/10.52403/ijhsr.20230736
A Review Study of HIST Usage in Indian Patients – What Plays a Pivotal Role in the Indian Setting. (PMS-HIST Study)
Dr Bappaditya Kumar1, Dr K Mohan2, Dr Swapan De4, Rajesh Pandita4, Dr Rushikesh M Shah5
1Consulting Interventional Cardiologist, Hooghly, India
2Consulting Physician, M K Nursing Home, Chennai, India
3Sr. Interventional Cardiologist, Apollo Hospitals, Kolkata, India
4Department of Medico Affairs, Azkka, Ahmedabad, India
5Consulting Physician, Zydus Hospitals, Ahmedabad, India
Corresponding Author: Rajesh Pandita
ABSTRACT
Background: To examine the use of high-dose statin therapy in Indian patients, this post-marketing analysis aimed to understand physicians' responses to the use of HIST in CVD patients with high LDL cholesterol and triglycerides. Indians have a higher risk of CAD compared to Caucasians.
Main Body: A study was conducted in India where 1590 physicians received a questionnaire based on various parameters, data were collected and 1461 responses were finally included in the data analysis.
Recent lipid protocols recommend lowering low-density lipoprotein (LDL) cholesterol in patients with coronary heart disease. To validate the evidence for this recommendation, we conducted a clinical trial based on clinical experience in which physicians could share their views on statin use relative to their usual treatment.
Dyslipidaemia is the most important risk factor for myocardial infarction worldwide, Cholesterol levels are directly related to coronary artery disease in all studies.
A few years ago, randomized controlled trials showed that 1 mmol/L reduction in blood low-density lipoprotein (LDL) cholesterol with statin therapy was associated with a higher risk of heart disease. and death. Relative risk reduction (21% and 12%, respectively).
Conclusion: Overall, 87% of physicians prefer statin therapy for better clinical outcomes, as HIST is generally safe and effective. Compared with low-dose statin therapy for CAD and CVD, HIST provides additional benefits regardless of lower LDL cholesterol levels. Doctors recommend that patients at higher risk be treated with HIST.
More clinical studies are needed to determine which is the best LDL cholesterol target, the role of HIST in patients without heart disease, and the role of concomitant therapy.
Key words: High-Intensity Statin Therapy, Cardiovascular Disease, Coronary Atherosclerosis Disease, Flat Pricing