Review Article
Year: 2023 | Month: July | Volume: 13 | Issue: 7 | Pages: 122-135
DOI: https://doi.org/10.52403/ijhsr.20230719
Role of Circulating microRNA as a Potential Biomarker in Metastatic Breast Cancer
Ni Putu Yenny Kendarini1, Tjokorda Gde Bagus Mahadewa2, Ni Putu Tesi Maratni3, Putu Febry Krisna Pertiwi4
1Postgraduate Program, Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia
2Department of Brain Surgery, Faculty of Medicine, Udayana University, Denpasar, Bali/Prof. Ngoerah General Hospital, Denpasar, Bali
3Department of Biochemistry, Faculty of Medicine, Udayana University, Denpasar, Bali, Indonesia
4Faculty of Medicine Udayana University, Denpasar, Bali, Indonesia
Corresponding Author: Ni Putu Yenny Kendarini
ABSTRACT
Background: Breast cancer is the highest incidence among cancers in women, which diagnosed by tissue biopsy. These disadvantages, such as the invasive technique itself and the suffer from surgical procedure, make liquid or biofluid biopsies are further studied. The extracellualar or circulating microRNAs (miRNAs), has opened up new opportunities for early cancer diagnosis, because the method is non-invasive and simpler than tissue biopsies. Their presence in the circulation can be either cell-free or wrapped in vesicle membranes such as exosomes, microparticles, and apoptotic bodies, making miRNAs a potential biomarker in breast cancer. In addition, miRNA is currently being developed as a targeted therapy in breast cancer.
Methods: This literature was collected from significant journal databases, included published original article from 2005 until 2021. We only included freely accessible journals, using "miRNA breast cancer and circulating microRNA” as keywords.
Results: This review introduces a perspective on the function of miRNAs by illustrating their potential biomarker in diagnosis breast cancer.
Conclusion: miRNAs play an important role in regulating breast cancer development and their clinical role in diagnosis, prognosis and therapeutic targets in breast cancer patients.
Key words: microRNA, breast cancer, metastatic, biofluid biopsy