Original Research Article
Year: 2023 | Month: March | Volume: 13 | Issue: 3 | Pages: 116-125
DOI: https://doi.org/10.52403/ijhsr.20230311
A Randomized Clinical Study on Therapeutic Evaluation of Efficacy and Safety of a Polyherbomineral Unani Formulation in Hypothyroidism
Rafiuddin Khan1, Mohan Singh2, Azad Hussain Lone3, Arshad Hussain Shah4, Amanullah Haji5
1Department of Medicine and Dermatology, Markaz Unani Medical College & Hospital Kerela, India
2Director Ayush, Govt of J&K Kashmir
3Department of Dermatology, Govt Unani Medical College & Hospital Ganderbal Kashmir
4Department of Surgery, Govt Unani Medical College & Hospital Ganderbal Kashmir
5Department of Medicine, Govt Unani Medical College & Hospital Ganderbal Kashmir
Corresponding Author: Dr Azad Hussain Lone
ABSTRACT
Background:Primary hypothyroidism is the most common disease of thyroid gland. It is most prevalent disease affecting up to 40/10,000 in women and 6/10,000 in men each year. It leads to various complications such as myxedema, psychosis, myocardial infarction, congestive heart failure etc. and also adversely affects quality of life. The objective of present study was to evaluate safety and efficacy of a Polyherbal Unani formulation in the management of hypothyroidism on scientific parameters.
Methods: A randomized, single-blind, standard controlled study was conducted on 60 patients of primary hypothyroidism after taking informed consents and were randomly allocated to test (A) and control (B) groups. Group A was given Ployherbomineral Unani formulation (PHMUF) in the dose of 3 gm twice a day. While Patients of Group B were treated with the control drug, Thyroxine sodium (Eltroxine) 100 μ gm tablet orally once a day. The duration of treatment in both groups was 60 days. All the patients were kept under strict observation and assessment for subjective and objective parameters was done at 30 days interval. The results were analyzed statistically by using standard tests.
Results: The PHMUF exhibited statistically significant improvement on subjective parameters such as weight gain, cold intolerance, puffiness of face and lethargy in comparison to control group. But there was no significant effect of PHUF on objective parameters such as thyroid profile, Serum cholesterol and ECG in test group. However, there was significant effect on thyroid profile and Serum cholesterol (p<0.05) in control group. No significant effect was found in the control group on other objective parameters.
Conclusion: The study concluded that PHMUF is effective and safe in the symptomatic treatment of Primary hypothyroidism.
Key words: Primary hypothyroidism; Polyherbomineral Unani formulation; Thyroid Profile.