Original Research Article
Year: 2023 | Month: March | Volume: 13 | Issue: 3 | Pages: 1-4
DOI: https://doi.org/10.52403/ijhsr.20230301
The Diagnostic and Prognostic Value of C-Reactive Protein in Patients with Severe Bacterial Infection
Fathima Shahana Sherin1, Kavitha M K2
1Department of Medical Microbiology, CIHS, Thalassery, Kannur, Kerala, India
2Professor & HOD, Department of Medical Microbiology, CIHS, Thalassery, Kannur, Kerala, India
Corresponding Author: Kavitha M K
ABSTRACT
C-reactive protein (CRP) is an established biomarker for the assessment of inflammation and its severity in patients who present to hospitals and can be used as a reliable, fast and cheap indicator of the infection. Increase in the level of C-reactive protein and other acute phase protein contribute to defense mechanism in several ways. The present study shows the importance of diagnostic and prognostic function of C – reactive protein in patients with severe bacterial infection. The detection of CRP was done on automated chemical analyzer AGAPPE MISPA- i2. All the statistical analyses were performed using SPSS version 20. A total of 102 samples of patient who had severe infections were processed. In all these cases, Pair 1, that mean CRP in first day and CRP in 9th or 10th day of hospital admittance was having a mean value of 138.32mg/L and 15.48mg/L respectively. The mean value of Pair 2, that means CRP in first day and 4th or 5th day were 117.66 mg/L and 56.31mg/L respectively. And Pair 3 means CRP in 4th or 5th day and 9th or 10th day, the mean values are 66.56mg/L and 15.48mg/L respectively. The mean value obtained from the data shows the reduction in both CRP and infection simultaneously; from the onset of illness to curing of the disease. To conclude, the value of CRP can be used as a diagnostic and prognostic tool which indicate the severity of the infection during the early stages and the curing of infection in the late stages.
Key words: [C-reactive protein, biomarker, acute phase protein]