Year: 2023 | Month: November | Volume: 13 | Issue: 11 | Pages: 240-254
DOI: https://doi.org/10.52403/ijhsr.20231129
A Clinical Study of Cardiological Dysfunction in Non-Alcoholic Fatty Liver Disease in a Tertiary Care Hospital
Sumanta Chatterjee1, Bappaditya Kumar2, Somnath Mukhopadhay3
1Department of Cardiology, AMRI Hospital, Dhakuria, Kolkata, India
2,3Department of Cardiology, AMRI Hospital, Salt Lake, Kolkata, India
Corresponding Author: Bappaditya Kumar
ABSTRACT
Non-Alcoholic Fatty Liver Disease (NAFLD) is a term used to describe the accumulation of fat in the liver of people who drink little or no alcohol. Previous studies have shown a higher prevalence of left ventricular remodelling and diastolic dysfunction in patients with NAFLD but they all include patients with obesity, diabetes and/or hypertension, which are by themselves well known risk factors for cardiovascular dysfunction. Our aim was to find out the cardiological dysfunction in non alcoholic fatty liver disease patients without conventional cardiovascular risk factors as diabetes and hypertension. We performed a cross-sectional study in 70 non alcoholic fatty liver disease patients without hypertension, diabetes and 30 controls without NAFLD, with an aim to find out any cardiological dysfunction, its occurrence, nature and correlation, with simple and cost-effective means, such as echocardiography, electrocardiography and some relevant biochemical parameters. Cases and controls were subjected to detailed echocardiography examination, including tissue Doppler imaging. CRP, uric acid, lipid profile, liver function tests were done. Results were compared between cases and controls and suitable statistical analysis were done. Cases had higher waist circumference compared to controls, though BMI and body weight were not different. Blood pressure, blood sugar was similar between two groups. Serum triglyceride was more in NAFLD group. Though diabetes, hypertension was excluded,20 out of 70 patients met the criteria for metabolic syndrome. Left ventricular end diastolic diameter and left ventricular mass index were more in NAFLD group suggesting cardiac structural alteration. NAFLD patients also showed lower early diastolic velocity (E) and lower early to late diastolic flow (E/A), thus demonstrating diastolic dysfunction. Our study also showed a sensitive and specific cutoff value for LVMI, which can be very useful in Indian scenario.
So, our study demonstrated cardiological structural and functional alteration in NAFLD patients independent of conventional risk factors of diabetes, hypertension and obesity in Indian perspective, where it is recently emerging as a booming epidemic.
Key words: NAFLD, LVMI, Diastolic Dysfunction