Original Research Article
Year: 2022 | Month: February | Volume: 12 | Issue: 2 | Pages: 125-131
DOI: https://doi.org/10.52403/ijhsr.20220217
Prognostic Value of Serum Cholinesterase in Acute Organophosphate Poisoning
Arun Kumar Sah1, Rajesh Kumar Mandal2
1Consultant Physician, Department of Internal Medicine, Gajendra Narayan Singh Hospital, Rajbiraj, Nepal.
2Consultant Physician, Department of Internal Medicine, Bheri Hospital, Nepalgunj, Nepal.
Corresponding Author: Arun Kumar Sah
ABSTRACT
Background: Organophosphorus (OP) compounds are anti acetylcholinesterase, used abundantly as pesticides and often misused as poisoning agents. Irreversible inhibition of cholinesterase enzymes is attributed to the serious clinical outcomes in these patients. This study aims to identify the relationship between the serum cholinesterase (SChE) activity and outcome.
Material and Methods: A descriptive cross-sectional study conducted in the Department of Internal Medicine of Bir Hospital, Kathmandu from July 2019 to December 2019. 50 patients of OP poisoning were studied. Laboratory investigations including SChE activity were performed and their management and their outcomes were recorded and analyzed by using statistical package for social sciences (SPSS) version 20.
Results: Poisoning was more predominant in young adults of the age group of 15 to 35(68%) years. Most common compound used for poisoning was chlorpyriphos 50% + cypermethrin 5% followed by dichlorvos 85% and cypermethrin. Among 50 cases 48 cases were discharged after successful management while 2 cases expired. No significant relation between initial serum level of acetylcholinesterase and outcome was observed in this study with p- value >0.05. Significant relation between initial serum acetylcholinesterase level, duration of hospital stay, atropinization dose and hospital arrival time from ingestion of poison was found with p- value of <0.05.
Conclusion: There was a significant correlation between SCH levels and total atropinization dose, duration of hospital stay and hospital arrival time. However no significant correlation was found for the clinical outcome and need of mechanical ventilator.
Key words: organophosphorous poisoning, serum acetylcholinesterase, cholinesterase.