Original Research Article
Year: 2022 | Month: December | Volume: 12 | Issue: 12 | Pages: 1-6
DOI: https://doi.org/10.52403/ijhsr.20221201
Genetic Predisposition of TNF-α (-308), TGF-β-1 (-508) and IL-35(EBI3) Gene Polymorphisms towards Rheumatic Heart Disease in the Population of Telangana from South India
Prashant Chilliveri1, Baluka Vanitha1, Y. Shiva Kumar2, Shehnaz Sultana3, P.P. Reddy1,4
1Bhagwan Mahavir Medical Research Centre, Hyderabad, Telangana, India.
2Mahavir Hospital & Research Centre, Hyderabad, Telangana, India.
3Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, Telangana, India.
4MAA Research Foundation, Hyderabad, Telangana, India.
Corresponding Author: P.P. Reddy
ABSTRACT
Background: Rheumatic Heart Disease (RHD) is a complex disease, subject to genetic and environmental factors. Cytokines play an important role in development and pathogenesis of the rheumatic heart disease. TNF-α, TGF-β and IL-35 gene polymorphisms may affect the expression levels of cytokines which may lead to damage to the heart valves.
Objective: This study was intended to explore the association of TNF-α, TGF-β and IL-35 gene polymorphisms with RHD.
Materials and Methods: The present case control study consisted of 145 patients with rheumatic heart disease and 217 control subjects in the same age group. Genotyping was done for the TNF-α (-308), TGF-β-1 (-508) and IL-35(EBI3) gene polymorphisms in both case and control groups.
Results: The results showed Bone differences in the distribution of genotypes in TNF-α, TGF-β and IL-35 genes RHD cases and control groups. However, the statistical analysis of the data showed the differences in the genotypes between TNF alpha (-308 G>A), TGF-β-1 (C-508T) and IL-35 EBI3G/C genes RHD case and control subjects were not found to be statistically significant.
Conclusion: In conclusion our study could not find any significant association between TNF-α (-308), TGF-β-1 (-508) and IL-35(EBI3) gene polymorphisms and RHD.
Key words: Rheumatic Heart Disease, Cytokines, Tumour Necrosis Factor alpha, Transforming growth factor beta 1, Interleukin, Single Nucleotide Polymorphism.