Original Research Article
Year: 2022 | Month: October | Volume: 12 | Issue: 10 | Pages: 132-139
DOI: https://doi.org/10.52403/ijhsr.20221017
Dyslipidemia in Prediabetes Population: A Retrospective Study of 91780 Cases
Dr. Shimi Sundharan1, Dr. Shibani Ramchandran2, Raj Jatale3, Dr. Kirti Chadha4
1,2,3,4Medical Affairs, Metropolis Healthcare Ltd, Mumbai, Maharashtra India Pin code: 400070
Corresponding Author: Dr. Shibani Ramchandran
ABSTRACT
Dyslipidemia over time leads to atherogenesis in both diabetics as well as prediabetics. The study aims to assess the correlation if any between the blood glucose levels [HbA1c] and the lipid cholesterol levels among the prediabetes group.
Method: A total of 91780 cases were reviewed across India from the same group of laboratory across 7 years from Jan 2015 to May 2022. The lipid profiles and glycated haemoglobin [HbA1c] were tested in all of them. The separation and quantification of hemoglobin A1c (HbA1c) in EDTA whole blood was done on the Tosoh HLC-723 G8 glycohaemoglobin analyzer, an ion exchange HPLC instrument. Analysis of reports of lipid profile which includes triglycerides, total cholesterol, HDL cholesterol LDL cholesterol was done using enzymatic colorimetric test method on Roche analyzer. The prediabetes group was classified based on the HbA1c levels and the lipid profile levels were analysed among them.
Results: The analysis showed percentage of prediabetes cases was 40.36%. Age group of >60 years had the maximum prediabetes cases (79.65%), whereas female group had slightly higher proportion prediabetics then males (62.09% VS 61.05%). Prediabetes group showed a significant association with borderline HDL (OR: 1.14, p value <0.0001), major risk HDL (OR: 1.33, p value <0.0001), desirable non HDL cholesterol (OR: 1.31, p value <0.0001), borderline high non HDL cholesterol (OR: 1.54 p value <0.0001), high non HDL cholesterol (OR: 1.60, p value <0.0001) and very high non HDL cholesterol (OR: 1.65, p value <0.0001). We also observed a significant association of borderline high triglycerides (OR: 1.22, p value <0.0001) and high triglycerides (OR: 1.89, p value <0.0001). High VLDL was also associated with pre diabetics (OR: 1.31, p value <0.0001).
Conclusion: The study showed that most of the lipid profile parameters were higher in the prediabetes group as compared to the healthy non-diabetic group. The HDL levels were shown to be lower among the prediabetics as compared to the non-diabetics. A mandatory lipid profile screening among prediabetes patients will prevent further cardiovascular risk among them.
Key words: Diabetes, prediabetes, glycated haemoglobin [HbA1c], dyslipidaemia, high density lipoprotein [ HDL], Low density lipoprotein [LDL], cholesterol