Original Research Article
Year: 2021 | Month: May | Volume: 11 | Issue: 5 | Pages: 30-37
DOI: https://doi.org/10.52403/ijhsr.20210504
Clinical Profile and Laboratory Findings of Dengue Fever in Children
Mahesh Ahirrao1, Ashish Patil2, Anjali Kurup3, Aditya Thorat4, Komal Shivnani5, Suriya Patil6
1Professor, Department of Pediatrics, ACPM Medical College, Dhule
2Junior Resident 3, Department of Pediatrics, ACPM Medical College, Dhule
3Junior Resident 3, Department of Pediatrics, ACPM Medical College, Dhule
4Junior Resident 2, Department of Pediatrics, ACPM Medical College, Dhule
5Junior Resident 2, Department of Pediatrics, ACPM Medical College, Dhule
6Junior Resident 2, Department of Pathology, PDMMC, Amravati
Corresponding Author: Ashish Patil
ABSTRACT
Background: Dengue is an arthropod borne viral hemorrhagic fever. It is a major public health concern throughout the tropical and subtropical regions of the world.
Objectives: To study clinical profile and laboratory findings of dengue infection in children.
Materials and Methods: Children up to the age of 15 years who were confirmed serologically dengue positive (either positive NS1 antigen or positive IgM antibody by ELISA method were included in study. Total 100 patients were studied. Pre tested, semi structured questionnaire were developed and used for data collection.
Result and Discussion: In current study, maximum patients were found in Dengue Hemorrhagic Fever (DHF) group (68%), followed by Dengue Fever (25%). Fever was most common clinical manifestation. Maximum patients in this study were in 10 to 15 years of age group, male being more commonly affected. Thrombocytopenia and leukopenia were present in 90% and 69% of patients respectively.
Conclusion: School going children were more exposed to mosquito bites during day time school activities, thus maximum patients were from 10 to 15 years of age group. In early diagnosis of dengue fever, ELISA NS1 antigen is seen more promisable. When used in combination with ELISA IgM antibody, it significantly improves the diagnostic algorithm. Thrombocytopenia is more consistent feature of Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS).
Key words: Dengue Hemorrhagic Fever (DHF), Dengue Shock Syndrome (DSS), ELISA NS1 antigen, ELISA IgM antibody.