Original Research Article
Year: 2021 | Month: March | Volume: 11 | Issue: 3 | Pages: 198-204
Association and Sensitivity of Serum Uric Acid Levels with Certain Anthropometric Parameters in Overweight and Obese Subjects
Shivam Verma1, Narsingh Verma2, Sunita Tiwari3, Dileep Kumar Verma4
1Junior Resident, Department of Physiology, King Georges Medical University, Lucknow
2Professor, Department of Physiology, King Georges Medical University, Lucknow
3Professor & Head, Department of Physiology, King Georges Medical University, Lucknow
4Professor, Department of Physiology, King Georges Medical University, Lucknow
Corresponding Author: Narsingh Verma
ABSTRACT
Introduction: Metabolic syndrome is a significant medical morbidity progressing to cardiovascular complications both in developing and developed world. Uric acid is produced during metabolism of nucleotide and adenosine triphosphate (ATP) and contains the final product of human purine metabolism. It acts both as an antioxidant and pro-inflammatory marker and has positive association with visceral fat in overweight subjects.
Methodology: The study included 124 urban obese and overweight Indian subjects above 18 years of age from general population of city of north India, who were free of any known underlying disease. Uric acid concentrations were measured by the uricase method. Anthropometric measurements and information on lifestyle factors and disease history were collected by in-person meeting.
Results: Body mass index (BMI), waist-to-hip ratio (WHR), weight and sagittal abdominal diameter (SAD) were positively correlated with the serum uric acid level and result was highly significant.
Conclusion: In present study, we found that serum uric acid level increases as body fat content increases. Statistical data shows remarkable results for significant correlation of uric acid level with BMI, WHR and SAD. Hypertrophy occurs as a result of Inflammatory processes and oxidative stress when the supply of energy starts to exceed the storage capacity of adipocytes, as a result adipokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor-necrosis factor alpha (TNF-α) are released more frequently which lead to low-grade chronic inflammation, that starts in adipose tissue and finally reaches the circulation and other organs. Antioxidants system including enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and non enzymatic substrates like as ferritin, transferrin, bilirubin, ceruloplasmin, carrier of albumin low molecular weight, like uric acid and lipoic acid controls oxidative stress. This shows uric acid levels are much lean towards visceral obesity than overall body fat content. Earlier studies also shows visceral adiposity is key factor for increasing oxidative stress and uric acid level.
Key words: Uric acid, Hyperurecemia, obesity, overweight, metabolic syndrome, inflammatory markers.