Original Research Article
Year: 2021 | Month: March | Volume: 11 | Issue: 3 | Pages: 182-189
A Comparative Study of Biochemical and Hematological Parameter in Non Dialysis Dependent Chronic Kidney Disease and Dialysis Dependent Chronic Kidney Disease Patients
Ojaswee Shrestha1, Anit Lamichhane1, 2, Tika B. Thapa1, Alaska Timilsina1, Puspa Raj Khanal1, 3, Vinay Singh1, Sujina Maharjan1
1Sumeru Hospital Pvt. Ltd., Lalitpur, Nepal
2Manmohan Institute of Health Sciences, Tribhuvan University, Kathmandu, Nepal
3Modern Technical College, Pokhara University, Lalitpur, Nepal
Corresponding Author: Anit Lamichhane
ABSTRACT
Introduction: CKD patients are at higher risk for development of anemia and decline in liver function associated with increased mortality rate. This study was conducted to access the hematological and liver parameters in DD-CKD and NDD-CKD patients.
Materials and Methods: This cross sectional study was conducted among 419 CKD patients attending Sumeru Hospital, Nepal. Among them 147 were dialysis dependent and 272 were non dialysis dependent CKD and its stages were diagnosed based on eGFR (CKD-EPI). Hematological, biochemical profile and viral infection were determined. ALT and Aspartate-Platelet ratio index were used respectively for the identification of hepatotoxicity and liver fibrosis.
Result: The Hb concentration, Platelets count, ALT and AST in DD-CKD patients (9.06 g/dL, 191 x 109Cells/L, 23U/L and 15 U/L) were lower as compared to NDD- CKD patients (12.41 g/dL, 206 x 109Cells/L, 29 U/L and 25.5 U/L). ALP was significantly increased in DD-CKD (141 U/L) as compared to ND-CKD (99 U/L). In addition, the occurrence of HCV and HBV infection was 3.1% each and HIV was 2.6%. Furthermore, the frequency of hepatotoxicity and liver fibrosis were found to be 12.9% and 8.1% respectively. The Pearson correlation of eGFR with Hb, Platelets, ALT, MCV, MCH were positively correlated whereas, it was negatively correlated with total WBC count and ALP.
Conclusion: The severity of anemia, leukocytosis, thrombocytopenia and liver deterioration increases along with the increasing severity of CKD and the severity are at highest in DD-CKD as compared to NDD-CKD patients.
Key words: DD-CKD, NDD-CKD, Hematology profile, Liver profile.