Original Research Article
Year: 2021 | Month: December | Volume: 11 | Issue: 12 | Pages: 83-90
DOI: https://doi.org/10.52403/ijhsr.20211213
Effects of Alpha-Tocopherol on Biochemical Parameters in Adult Mice
Franck Arnaud Moukobolo Kinsangou1,2, Henriette Poaty1,3, Dimitry Moudiongui Mboungou,1, Landry Martial Miguel1, Etienne Moukoundjimobe1, Jean Félix Peko1, Ange Antoine Abena1
1Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo
2Laboratory of Biochemistry, Centre Hospitalier Universitaire de Brazzaville, Brazzaville, Congo
3Institut National de Recherche en Sciences de la Santé (IRSSA), Brazzaville, Congo
Corresponding Author: Franck Arnaud Moukobolo Kinsangou
ABSTRACT
Background: Numerous reviews report the beneficial effects of alpha tocopherol in preventive supplementation and also as an adjuvant in the treatment of some pathologies (cardiovascular, cancers). In this work, we analyzed the effects of vitamin E at high doses on some biochemical parameters.
Methods: Thirty-two adult male and female mice (CD1 albino mice) were randomly selected for a 4-week experiment. The mice were supplemented with alpha tocopherol at doses of 150, 400 and 750mg/day. With a high dietary intake of vitamin E
Results: According to our analyses, we can note Excess weight predominated in groups 4 to 7.
All the blood lipid parameters showed an abnormal concentration, as of the 400 mg dose of α-T-acetate.
Hyperglycemia and hyperlipidemia were observed. These variations were more pronounced for total cholesterol and triglycerides than for HDL and LDL fractions.
Conclusion: The study showed significant effects of high-dose α-T supplementation on biochemical parameters, mainly hyperglycemia and dyslipidemia.
Key words: Vitamin E, Alpha-tocopherol, blood biochemical parameters.