Original Research Article
Year: 2021 | Month: November | Volume: 11 | Issue: 11 | Pages: 208-229
DOI: https://doi.org/10.52403/ijhsr.20211127
Antifungal Topical Nanoemulgel Containing Miconazole Nitrate
Anju K P1, Shripathy D2, Shabaraya A R3
1M.Pharm, Department of Pharmaceutics, Srinivas College of Pharmacy Valachil, Mangalore.574143, Karnataka, India.
2Assistant Professor, Department of Pharmaceutics, Srinivas College of Pharmacy, Mangalore, India.
3Principal, Department of Pharmaceutics, Srinivas College of Pharmacy, Mangalore, India.
Corresponding Author: Anju K P
ABSTRACT
Nanomulgel have emerged as one of the most interesting topical drug delivery system as it has dual release control system i.e. nanoemulsion and gel. Also the stability of nanoemulsion is increased when it is incorporated in gel. Miconazole nitrate is an antifungal medication topically administered to treat skin infections such as athlete’s foot, jock itch and ringworm. The aim of the present research work was to investigate the potential of nanoemulgel in enhancing the topical delivery of hydrophobic drug. MCZ nanoemulsions were prepared using span 80, tween 80, propylene glycol and different conc. of sunflower oil by High pressure homogenization technique. The prepared nanoemulsions were evaluated for pH, drug content, centrifugation, globule size and zeta potential.F2 showed highest drug content 91.26%.The globule size are found to be satisfactory range of nanoemulsion. The drug release kinetics is in the order of F2>F3>F4>F5>F1.And Nanoemulgel is prepared by using Carbopol 934 as gelling agent The release kinetics of nanoemulgel was found to obey zero order kinetics. The nanoemulgel was found to be stable with respect to physical appearance, pH, rheological properties spreadability and drug content at all temperature and conditions for two month. Hence, in the present study it can be concluded that Miconazole Nitrate nanoemulgel formulation is a promising system for the topical drug delivery and also an alternative method to deliver the hydrophobic drugs in water soluble gel bases.
Key words: Hydrophobic drugs, Nanoemulgel, Miconazole nitrate, Topical drug delivery.