Original Research Article
Year: 2020 | Month: June | Volume: 10 | Issue: 6 | Pages: 286-290
Epidemiology, Characterization and Antifungal Susceptibility Profile of Candida Species Isolated From Suspected Cases of Urinary Tract Infections at Tertiary Care Centre of North Delhi
Sanjay Jain1, Nadeem Ahmad2, Sushil Tomar3
1HOD, 2Assistant Professor, 3Senior Resident, Microbiology, North DMC Medical College & Hindu Rao Hospital, Malka Ganj, Delhi-110007
Corresponding Author: Nadeem Ahmad
ABSTRACT
Purpose: Funguria is a condition characterized by the presence of fungus in urine. It is a common finding at tertiary care hospitals across the globe. There is limited literature on fungal profile in funguria cases especially from our country. This study was undertaken to know the fungal profile amongst candiduria cases and to know the antifungal susceptibility profile of different isolates at a tertiary care hospital in North Delhi.
Methods: Culture & sensitivity testing of two consecutive mid stream urine samples from suspected cases of urinary tract infection was done at the Department of Microbiology, North DMC Medical College & Hindu Rao Hospital. Yeast like isolates obtained were further speciated by conventional methods by Gram staining, germ tube test, growth on corn meal agar with Tween 80, colony colour on CHROM agar candida medium, and VITEK 2 System. Antifungal susceptibility testing of Candida isolates was performed using VITEK 2 System
Results: In this study, out of 4838 urine samples, 50 yeast like isolates were obtained. In these, 33 were from OPD clinics and 17 were from indoor wards. Of the 50 Candida isolates, 18 (36%) and 32 (64%) were from male and female patients respectively. The male to female ratio was 0.56. In our study, Candida albicans was the most common species isolated followed by C.tropicalis, C.glabrata and C. parapsilosis. In this study, 84% Candida species were sensitive to Fluconazole,92% to Voriconazole,88% to Caspofungin,86% to Amphotericin B and 88% to Flucytosine.
Conclusion: Our study will help in identifying the common candida spp. and their antifungal sensitivity pattern in cases of fungal urinary tract infections.
Key words: Fungal UTI, Candida albicans, Fluconazole resistance