Original Research Article
Year: 2020 | Month: May | Volume: 10 | Issue: 5 | Pages: 115-120
Relationship of Adiponectin with Liver Enzymes in NAFLD Subjects
Charu Gunjal1, Ankita Sharma2, G.G. Kaushik3, Manjubala Maheriya1
1M.Sc. student, 2Sr. Demonstrator, 3Sr.Professor,
Department of Biochemistry, J.L.N. Medical College, Ajmer.
Corresponding Author: Ankita Sharma
ABSTRACT
NAFLD is a complex metabolic condition in which excessive fat gets accumula¬ted in the liver of patients in absence of immoderate alcohol consumption. The increased fat content of the liver correlates positively with the insulin resistance that characterizes metabolic syndrome. Adipokines are hormones secreted by Visceral adipose tissue which are implicated in development of obesity and pathogenesis of Insulin resistance (IR). Recently, there is great enthusiasm in studying their potential role in the pathogenesis of NAFLD. The aim of this study was to determine the validity of adiponectin (non-invasive parameter) for Non-alcoholic fatty liver disease and to investigate the correlation between serum levels of this adipokine and liver enzymes in patients with Non-alcoholic fatty liver disease in Indian population. 84 USG proven NAFLD subjects and 84 healthy non-obese age and gender matched controls were studied. Serum concentrations of ALT, AST, GGT, ALP and Adiponectin levels were assessed. The study showed that serum adiponectin is statistically significantly lower in patients with NAFLD than in control group. Serum adiponectin and liver enzymes were significantly inversely correlated in NAFLD subjects. Hence, it is concluded that in addition to liver enzymes, adiponectin (non invasive parameter) can also be used as diagnostic measure for NAFLD subjects.
Key words: Adiponectin, NAFLD, Liver Enzymes