Original Research Article
Year: 2020 | Month: February | Volume: 10 | Issue: 2 | Pages: 150-158
Seroprevalence and Determinants of Hepatitis B among Blood Donors in the University Clinics of Kinshasa (2003-2006, 2008- 2013)
Blaise Matondo Manzambi Sumbu1, Benjamin Longo-Mbenza1,2,4, Aliocha Nkodila Natuhoyila4,7, Mireille Nganga Nkanga1, Jérémie Muwonga Masidi1, Hortense Mbumba Maphana3, Donatien Kayembe Nzongola-Nkasu1, Georges Mvumbi Lelo1, Hyppolite Situakibanza NT1, Ferdinand Mbayo Kalumbu1, Hervé Alex Tukadila Kabangi4, , Raphael Taty Taty5, Moulay Mustapha Ennaji6, Steve Ahuka-Mundeke1,2
1University of Kinshasa, Kinshasa, DR Congo
2National Institute of Biomedical Research (INRB), Kinshasa
3Target Sprl.
4Lomo University of research, Kinshasa, Democratic republic of Congo,
5Faculty of Health Sciences, Marien Ngouabi University. Brazzaville, Republic of Congo, Hospital and University Center. Brazzaville, Republic of Congo,
6Faculty of Sciences and Techniques Mohammedia Hassan II University of Casablanca, Morocco
7Centre Medical Cite des Aveugles, Mont Ngafula, DR Congo
Corresponding Author: Aliocha Nkodila Natuhoyila
ABSTRACT
Background: Blood transfusions carry higher risk of transmitting infections such as HBV. The University of Kinshasa Clinics has a crucial mandatory role for pre-transfusion screening of blood transmitted-transfusion infections.
Objective: The aim of this study was to analyze the prevalence and the trends of HBV seropositivity among blood donors
Methods: A retrospective analysis was carried out at University Kinshasa Clinics, using Blood donors records during 2003 - 2006 and 2008 – 2013. Frequencies of HBV per year, age, sex and type of blood donors (volunteer- Blood donors and familial- Blood donors) were calculated and compared for association with TTI using univariate and multivariate logistic regression analyses after adjusting for confounders to identify significant independent determinants of TTI.
Results: Out of 26’341 Blood donors, 4% (n=1,057/26,341) were seropositive for HBV.
Age<55 years (OR= 1.5; 95%CI 1.1 – 2; P+o.oo8), HIV seropositivity (OR=1.5; 95%CI 1.03 – 2.1; P=0.033), and years 2009, 2011 and 2012(OR=1.5; 95%CI 1.03 – 2.1; P=0.033) were the independent determinants of HBV seropositivity.
Conclusion: This study shows an inverted U – shaped relationship between HBV related to young adults (Peak in 2011) and over time. Urgent further research, policy, health systems, intervention of the government, university authorities, and staff of blood transfusion unit are needed to minimize the mass problem of HBV at University of Kinshasa Clinics.
Key words: Blood donor, HBV, serology, prevalence, DRC