Review Article
Year: 2019 | Month: March | Volume: 9 | Issue: 3 | Pages: 306-314
Role of Sugar in Gall Bladder Carcinoma- A Review
Anindita Deb Pal
Assistant Professor, Department of Food Science and Nutrition Management, J. D. Birla Institute, Kolkata, India
ABSTRACT
Sugar, the known poison has long been associated with the etiology of several chronic diseases including coronary disorders, metabolic diseases as well as cancer. Excessive consumption of the above interferes with normal cell signaling and metabolism thereby leading to development of physiological and metabolic stress. The present article highlights the involvement of sugar in the development and progression of gall bladder carcinoma. Gall bladder tumors rank fifth amongst the cancers of the liver and biliary tract. This type of cancer is generally associated with late diagnosis, poor prognosis and the paucity of targeted treatment options. Imbalanced intake of sugar rich food and beverages induces hyperinsulinemia, insulin resistance and diabetes mediated predisposition towards gall bladder carcinoma. Their consumption also elevates the chances of abnormal BMI, obesity as well as development of gall stones; all of which play a pivotal role in the manifestation of the above. These factors ultimately lead to the activation and upregulation of Insulin Dependent Growth Factor I (IGF) and its receptor (IGFR-1) which ultimately promotes tumorigenesis through modulation of cell growth, differentiation and inflammatory pathways. Therefore regular consumption of a balanced diet and maintenance of a healthy lifestyle may aid in prevention of numerous ailments including gall bladder cancer. Moreover, dietary interventions may also add on to the existing avenues of cancer prevention and therapy.
Key words: Diabetes, gall bladder cancer, gall stones, IGF, insulin, obesity, sugar,