Original Research Article
Year: 2019 | Month: February | Volume: 9 | Issue: 2 | Pages: 77-83
Histopathological Study of Prostatic Diseases in B.P.K.I.H.S, Nepal:A Hospital Based Study
Rajan Shah1, Smriti Karki1, Niharika Shah1, Sushil Dhakal1, Sudhir Kumar Singh2, Rajendra Kumar Chaudhari3
1Department of Pathology, 2Department of Surgery, 3Department of Biochemistry,
B. P. Koirala Institute of Health Sciences (B.P.K.I.H.S), Nepal
Corresponding Author: Rajan Shah
ABSTRACT
Introduction: Carcinoma of prostate is one of the common tumors of elderly men causing significant morbidity and mortality. Other prostatic pathology ranged from inflammatory lesions to benign prostatic hyperplasia (BPH). Gleason score (GS) combined with grade and pathological stage for prostate carcinoma correlates with clinical behavior and is best marker for predicting prognosis.
Objective: To evaluate the histopathological spectrum of various prostatic lesions in biopsy specimen at B.P.K.I.H.S
Methods: A hospital based descriptive cross sectional study over a period of one year was carried out on biopsy specimen received at histopathology laboratory in the department of pathology. Histopathology slides were assessed and categorized into different groups. Prostate carcinoma was graded according to new grading system.
Results: BPH was the commonest encountered lesion seen in the prostate (62.79%). Prostatitis in 13.9%. Prostatic adenocarcinoma was found in about 23.3%, no cases of PIN were documented. Majority of these cases were of high grade adenocarcinoma (Grade Group 4 and 5) with frequent Gleason score 8-10. (P <0.0001)
Conclusion: Various spectrums of prostatic lesions in different age groups were determined. Histopathological study with thorough examination of biopsy section is mandatory to detect malignancy. Increase awareness of prostate malignancy with advancing age and timely mass screening of prostatic lesion is recommended to reduce mortality.
Key words: Benign prostatic hyperplasia, Gleason score, Prostatic adenocarcinoma.