Original Research Article
Year: 2019 | Month: January | Volume: 9 | Issue: 1 | Pages: 69-75
Clinical Evaluation of Co-enzyme Q10 in Management of Chronic Periodontitis Patients: Mouth Split Study
Ali K. Barakat1, AlaaMoustafa Attia2
1Dental intern, Faculty of Dentistry, Umm Alqura University, Saudi Arabia.
2Associate Professor of Oral medicine and Periodontology, Faculty of Dentistry Al-Azhar University (Assiut), Egypt and Umm Alqura University, Saudi Arabia.
Corresponding Author: Ali K. Barakat
Background: Co-enzyme Q10 (CoQ10) is an antioxidant agent which can suppress the inflammatory process in periodontium. Some studies investigated the effectiveness of this agent as an adjunctive to non-surgical periodontal therapy.
Aim: the present study aimed to evaluate the effectiveness of CoQ10 gel in management of chronic periodontitis patients as an adjunctive periodontal therapy.
Materials and Methods: Twenty chronic periodontitis patients (25-60 years old) were evaluated by the following clinical parameters: bleeding index (BI), plaque index (PI), probing pocket depth (PPD) and clinical attachment loss (CAL). They received non-surgical periodontal therapy on two visits, the CoQ10 gel was applied intra-pocket in the buccal right sites of jaws and packed by periodontal dressing for one week, while the left sites treated only by scaling and root planning (SRP). The patients were clinically evaluated after one month; the data were collected and statistically analyzed.
Results: In both quadrants treated by CoQ10/SRP and SRP only; the statistical comparisons of mean values for all parameters (PI, BI, PD, CAL) before and after treatment revealed highly significant difference (P £ 0.01). Before treatment in both quadrants which treated by CoQ10/SRP and SRP, there is no statistical differences between the mean values of all clinical parameters (P ³ 0.05). Furthermore, statistical comparisons between the mean values of all clinical parameters after treatment in quadrants treated by CoQ10/SRP and SRP only revealed highly significant difference (P £ 0.01).
Conclusion: CoQ10 gel intra-pocket applications packed by periodontal dressing provide precious clinical outcomes and considered as a useful adjunctive agent with non-surgical periodontal therapy.
Key words: Chronic periodontitis, Intra-pocket, Co-enzyme Q10 gel.