Original Research Article
Year: 2018 | Month: September | Volume: 8 | Issue: 9 | Pages: 35-42
Histomorphological Profile and Clinicopathological Correlation of Soft Tissue Tumours-A Study at a Tertiary Care Teaching Hospital
Dr. Vaidehee Naik1, Dr. Hoogar M.B2, Dr. Shilpi Sahu3, Dr. Ruchi Khadayate4
1Senior Post-Graduate Resident, 2Associate Professor, 3Professor and Head, 4Junior Post-Graduate Resident,
Department of Pathology, MGM’s Medical College, Navi Mumbai
Corresponding Author: Dr. Vaidehee Naik
Introduction: Soft tissue is defined as nonepithelial extraskeletal tissue of the body exclusive of the reticuloendothelial system, glia and supporting tissue of various parenchymal organs. Soft tissue tumours (STS) are a heterogeneous group of soft tumours classified according to the line of differentiation of adult soft tissues and the pathogenesis most of which is not known.
Objectives: The main objectives of the present prospective study are to determine the overall incidence of soft tissue tumours and their frequency of distribution in relation to age, sex and various sites in the body, and to study the histomorphological features which would help in classification and subclassification of soft tissue tumours.
Methods: The present prospective study was conducted between July 2016 and December 2017 for a period of 18 months in a tertiary care teaching hospital.
Results: Out of 113 soft tissue tumours analysed in the present study, 95.5% are benign in nature and 4.5% are malignant with benign lipomatous tumours (55.7%) being most common soft tissue tumours, followed by benign vascular tumours (19.46%). Incidence of soft tissue tumours is found to be higher in males; the incidence being highest in the age group of 31-40 years.
Conclusion: Soft tumours pose diagnostic challenges because of confounding morphological characteristics, which might need utmost diligence and advanced ancillary studies such as immunohistochemistry and molecular studies for accurate diagnosis and clinicopathological correlation. In the present study, the incidence of benign tumours (95.5%) is higher than malignant tumours with benign lipomatous tumours (55.7%) being most commonly occurring tumours with maximum age incidence being 31-40 year-age group in a total cases analysed being 113. The incidence of soft tissue tumours is higher in males having with the male to female ratio being 1.13:1 with commonest site of occurrence being upper extremities.
Key words: Soft tissue tumours, round cell tumours, benign and malignant soft tissue tumours, lipomatous tumours, spindle cell lesions, fibrohistiocytic tumours