Year: 2018 | Month: July | Volume: 8 | Issue: 7 | Pages: 327-336
A Short Review of Biologic Aspect of Human Papilloma Virus (HPV) in Head and Neck Region
Deepa Jose1, Deepa Rajesh2, Dr Jasmine Jose3
1Senior Lecturer, Department of Oral Pathology, Government Dental College, Kottayam.
2Reader, Department of Oral Pathology, KLE VKIDS, Belgaum
3Senior Resident, Department of Oral Pathology, Government Dental College Kottayam.
Corresponding Author: Deepa Jose
Human Papillomavirus (HPV) is a small DNA virus of ~55nm in diameter, which infects the squamous epithelium of the skin or mucosa and can lead to pathologies ranging from infections to benign or malignant lesions. Although high-risk HPVs have been detected in malignant and potentially malignant oral lesions, they have also been found in the normal oral mucosa. Understanding the role of HPV in oral carcinogenesis is complicated by different frequencies varied from 0-100% in premalignant and malignant lesions, probably due to differences in sampling or analyzing methods. HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) is genetically distinct from HPV-negative cancer with respect to patterns of loss of heterozygosity, chromosomal abnormalities, and gene-expression profiles. A better understanding of HPV and its associated lesions are essential for the development of HPV targeted strategies.
Key words: Human Papillomavirus, HPV, DNA virus, oropharyngeal squamous cell carcinoma (OPSCC).