Year: 2018 | Month: May | Volume: 8 | Issue: 5 | Pages: 411-414
Dengue Fever End Up with Immune Thrombocytopenic Purpura
Senior Lecturer in Medicine, Department of Clinical Sciences, Faculty of Health Care Sciences, Eastern University, Srilanka.
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by low platelet count and skin-mucosal bleeding. It commonly affects adult female in an idiopathic and chronic manner. Thrombocytopenia associated with dengue viral infection seems to result in both from a reduction in the production of platelets from megakaryocytes and from a decrease in the half-life of the platelets. The mechanisms behind thrombocytopenia are many. Persistent low platelets are not a feature of dengue fever. Furthermore, low platelets of dengue fever do not respond to steroids. It has been reported that acquired immune TTP is closely associated with Epstein Barr virus, cytomegalovirus, human immunodeficiency virus infection and influenza infection or vaccination. We herein report the first case of acquired TTP associated with dengue haemorrhagic fever in the east part of the SriLanka.
Key words: Dengue fever, Immune thrombocytopenic purpura, and low platelet count.