International Journal of Health Sciences and Research

| Home | Current Issue | Archive | Instructions to Authors |

Original Research Article

Year: 2018 | Month: May | Volume: 8 | Issue: 5 | Pages: 135-139

Evaluation of Gingival Crevicular Fluid and Serum Levels of Interleukin-20 in Periodontal Health and Disease

Bashar A. Alzubaidy1, Alaa Moustafa A2, Abdel-Rahman Youssef3

1Dental intern, Faculty of Dentistry, Umm Alqura University, Saudi Arabia.
2Associate Professor of Oral medicine and Periodontology, Faculty of Dentistry - Al-Azhar University (Assiut), Egypt and Umm Alqura University, Saudi Arabia.
3Assistant Professor of Microbiology and Immunology, Faculty of Medicine, Umm Alqura University, Saudi Arabia and Suez Canal University Egypt.

Corresponding Author: Alaa Moustafa A


Periodontitis is a chronic inflammatory disease that causes destruction of tooth-supporting tissues. Interlukin-20 (IL-20) is a proinflammatory cytokine of the IL-10 family that is involved in some diseases; rheumatoid arthritis, psoriasis, and atherosclerosis. The purpose of this study was to evaluate the levels of IL-20 in gingival crevicular fluid (GCF) and serum of both chronic periodontitis patients and periodontal healthy subjects. Thirty systemically male subjects were categorized into group 1 (healthy) and group 2 (chronic periodontitis patients). The patients were clinically evaluated by; plaque index (PI), bleeding index (BI), probing pocket depth (PD) and clinical attachment loss (CAL). GCF and serum samples were obtained from all individuals to measure IL-20 levels by using of enzyme-linked immunosorbent assay (ELISA) technique. The levels of IL-20 in GCF were significantly higher in chronic periodontitis patients compared to healthy subjects (P ≤ 0.05). In addition, there was a positive correlation between GCF-IL-20 levels and PD (r = 0.800, P= 0.010). While, the serum levels of IL-20 in chronic periodontitis patients were not significant in comparison to healthy subjects (P ≥ 0.05). For Conclusion, significant increased levels of GCF-IL-20 in chronic periodontitis patients showed that IL-20 may have a role in pathogenesis of chronic periodontitis. Moreover, additional studies are required to clarify its role in periodontal diseases.

Key words: IL-20, GCF, Serum, Chronic periodontitis

[PDF Full Text]