Original Research Article
Year: 2018 | Month: May | Volume: 8 | Issue: 5 | Pages: 97-103
A Comparative Study of Combination Therapy of Palonosetron plus Dexamethasone versus Dexamethasone Alone For Prophylaxis of Postoperative Nausea and Vomiting In Elective Surgery under General Anaesthesia
Dr. Ningthoujam Anita Devi1, Dr. Longjam Eshori Devi1, Dr. Aditi Bhattacharya2, Dr. Takhelmayum Hemjit Singh3, Dr. Dipanka Debnath2
1Associate Professor, 2PGT, 3Assistant Professor,
Department of Anaesthesiology, Regional Institute of Medical Sciences, Imphal, Manipur.
Corresponding Author: Dr. Longjam Eshori Devi
Background: Postoperative nausea and vomiting is an unpleasant and distressing adverse effect after anaesthesia and surgery which may result in wound dehiscence, bleeding, dehydration, electrolyte imbalance, pulmonary aspiration of gastric contents and delayed hospital discharge leading more expenses to the patient. Multiple studies were being conducted to find out an amicable solution to this problem.
Aims and Objectives: The study was to compare the efficacy of preoperative palonosetron plus dexamethasone combination therapy versus dexamethasone monotherapy for the prevention of postoperative nausea and vomiting (PONV) following any elective surgery under general anaesthesia.
Methods: It was a prospective, randomized controlled and double blind study where 100 patients of either sex, ASA I & II, aged 18-65 years were enrolled to receive either10 mg dexamethasone and 0.075 Palonosetron or 10 mg dexamethasone (total volume of 5 ml made with normal saline) slow IV, 10 minutes before induction of anaesthesia.
Results: During the first 24 hours postoperative, the incidence of nausea, retching and vomiting in the palonosetron plus dexamethasone group were 20%, 18% and 16% respectively and lesser as compared to 40%, 30% and 38% in the dexamethasone group alone, with p=0.04, p=0.24 and p=0.02 respectively. Complete response was more in the palonosetron plus dexamethasone group (80% versus 60%) with p=0.04
Conclusion: The study showed that prophylactic administration of intravenous palonosetron plus dexamethasone can effectively control postoperative nausea and vomiting as compared to dexamethasone alone.
Key words: PONV, Combination, Palonosetron, Dexamethasone.