Original Research Article
Year: 2018 | Month: April | Volume: 8 | Issue: 4 | Pages: 32-37
Product of Free Radical Injury and Antioxidant Status in Patients with Gestational Diabetes Mellitus (GDM)
Adeniran Samuel Atiba1, Babatunde Ajayi Olofinbiyi2, Olusola Peter Aduloju2, Rasaq Akintunde Akindele3, Kayode Tolorunju 4, Daniel Adebode Adekanle3
1Department of Chemical Pathology, Ekiti State University, Ado-Ekiti
2Department of Obstetrics and Gynaecology, Ekiti State University, Ado-Ekiti
3Department of Obstetrics and Gynaecology, Ladoke Akintola University of Technology, Ogbomoso.
4Department of Chemical Pathology, Ekiti State University Teaching Hospital, Ado-Ekiti
Corresponding Author: Adeniran Samuel Atiba
Objective: This was to determine oxidant and antioxidant status of patients with GDM
Methods: Total of 31 pregnant women with GDM and 51 patients with physiologic pregnancy were successfully recruited into the study. Gestational diabetes mellitus was diagnosed taking into consideration the guidelines of IADPSG and WHO in the course of oral glucose tolerance test (OGTT). Blood sample was also taken for the laboratory analysis of malondialdehyde (MDA), glutathione peroxidase (GPx) and superoxide dismutase (SOD).
Results: Higher plasma concentration of MDA though not statistically significant (p=0.305) was observed in patients with GDM (5.75±0.60 µmol/l) than patients with Non GDM (4.55±0.55 µmol/l). Lower plasma concentrations of GPx (2.98±1.10 Vs 3.12±0.78 U/ml, p=0.017) and SOD (69.33±21.94 vs86.47±24.26 U/ml, p=0.62) were observed in patients with GDM than patients without GDM
Conclusion: The study shows release of product of free radical injury (MDA) in excess of antioxidants (GPx and SOD) in patients with gestational diabetes mellitus.
Key words: Gestational Diabetes, free radical, antioxidants.