Original Research Article
Year: 2018 | Month: March | Volume: 8 | Issue: 3 | Pages: 11-18
Comparison of Different Concentration of Dextrose as an Adjuvant to Levobupivacaine in Lower Limb Surgeries: A Randomised Double-Blinded Controlled Trial
Dr Alka Verma1*, Dr Geeta Singariya2*, Dr Manoj Kamal3**, Priyanka Sethi4**, Dr Dilip Singh Chouhan5*, Kamlesh Kumari4*
1Resident, 2Professor, 3Associate Professor, 4Assistant Professor, 5Senior Professor,
*Dr S N Medical College, Jodhpur
**All India Institute of Medical Sciences, Jodhpur
Corresponding Author: Dr Geeta Singariya
Background: We compared the block characteristics and adverse effects along with the hemodynamic changes, following intrathecal administration of three different volume of dextrose to levobupivacaine in lower limb surgeries.
Material and methods: Seventy five patients were randomly allocated to three groups. In group I 50 mg dextrose, in group II 75 mg and in group III 100 mg was added to 0.5% levobupivacaine 1.5 ml (7.5 mg), total volume was made 2 ml by adding normal saline and injected intrathecally. The onset of sensory and motor blockade, duration of sensory and motor blockade, height of sensory block, two segment of regression time of sensory block hemodynamic changes and side effects were recorded.
Results: The onset of sensory block (to reach T12) was early in group II and III in comparison to group I (p=0.007, p<0.0001).The onset of motor block was 11.52±2.02 minute in group I, 9.64±1.11 minute in group II and 8.84±2.19 minute in group III. The mean time to reach maximum height of sensory block was less in group II and group III, in comparison to group I. The full recovery from sensory block was significant prolonged in group II and III compared to group I (p<0.0001). The total duration of motor block and time to urination was prolonged in group III compared to group I and II (p<0.0001).
Conclusion: Levobupivacaine with higher baricity had a faster sensory and motor onset as well as longer duration of sensory and motor block.
Key words: Spinal anaesthesia, dextrose, hyperbaric levobupivacaine, lower limb surgery.