Year: 2018 | Month: February | Volume: 8 | Issue: 2 | Pages: 272-287
Beneficial Effects of Sesamol, Hesperidin, Quercetin and Phloroglucinol in Parkinson’s Disease Models- A Review
1Research scholar, 2Associate Professor, Department of Biochemistry, Bharathi Women’s College, Chennai, Tamil Nadu, India
Corresponding Author: Vijayalakshmi.K
Parkinson’s disease is the progressive degeneration of dopaminergic neurons that constitute motor deficits. Current Parkinson’s disease therapies deal with the symptoms and do not halt the disease progression. The interest on bioactive compounds for the treatment of Parkinson’s disease is mounting now. Treatments for Parkinson’s disease to be included with prevention of brain cell dysfunction and death. Hence, we attempted to study the bioactive compounds (sesamol, hesperidin, quercetin and phloroglucinol) in Parkinson’s disease induced models. This article reviews the in vitro, in vivo and in silico approach of these four compounds. These four bioactive compounds have been reported to exert neuroprotective effects in various experimental models of Parkinson’s disease.
Key words: Parkinson’s disease, antioxidants, sesamol, hesperidin, quercetin, phloroglucinol