Original Research Article
Year: 2018 | Month: January | Volume: 8 | Issue: 1 | Pages: 25-35
Clinical, Bacteriology Profile, and Antibiotic Sensitivity Pattern of Catheter Associated Urinary Tract Infection at Tertiary Care Hospital
Harsha V. Patil1, Virendra C. Patil2
1Associate Professor, Departments of Microbiology, 2Professor, Department of Medicine,
Krishna Institute of Medical Sciences Deemed University, Karad, Satara, Maharashtra, India
Corresponding Author: Virendra C. Patil
Background: Urinary tract infection attributed to the use of an indwelling urinary catheter and is one of the most common infections acquired by patients in health care facilities.
Aims& Objectives: Clinical, bacteriology profile, and antibiotic sensitivity pattern of Catheter associated Urinary tract infection (CaUTI).
Settings and Design:This was a prospective observational study conducted over a period of 1 year from April 1, 2015, to March 31, 2016.
Materials and Methods: The patients fulfilling criteria of CaUTI were included in this study. The urine sample was processed by standard microbiological procedures. Organisms were isolated and antibiotic susceptibility performed.
Statistical Analysis: SPSS trial version 14.0 software and the values of P <0.05 were considered statistically significant.
Results: A total 146 were positive for bacterial growth on culture. Incidence of CaUTI was 21.31 per thousand catheter days. The overall incidence of CaUTI was 27.70% predominated by female population. Total 93 (63.69%) females and 53 (36.30%) males had CaUTI, predominated by female gender [‘p’<0.001]. The mean age of patient with CaUTI was more than patient without-CaUTI [Females-59.76(±12.69):44.75(±16.91); Males-61.72(±9.9):58.73(±17.32)]. The mean duration of Foley catheter in situ was more in patient with CaUTI than patients without CaUTI [14(±7.9): 9.5 (±6.7)]. Of total 146 bacterial isolates in patients with CaUTI54 (36.99%) were E. coli, 24 (16.44%) K. pneumoniae, 14(9.589%) P.aeruginosa, 12(8.219%), Enterococcus faecium 9(6.164%), A.baumanii complex, 23(15.75%) COPS, 5(3.425%) MRSA and 5 (3.425%) Serratiamarcescens. Total 106 (72.60%) were gram negative bacilli (GNB) and 40(27.39%) were gram positive cocci (GPCs) [‘p’< 0.0001]. The majority of GPCs were sensitive to Linezolid, tiechoplanin, nitrofurontoin and co-timaxozole. All MRSA were sensitive to Vancomycin. E coli and A. baumanii complex were sensitive to Tigecycycline, colistin, Meropenem and Amikacin. Majority of P.aeruginosa were sensitive to Colistin, Tigecycline, Meropenem, Imipenem, PI-TZ, Amikacin, Ceftazidime, cefepime and cefeperazone-sulbactum. K.pneumoniae were best sensitive to Colistin, Tigecycline, Meropenem, Imipenem, Aminoglycosides, Ceftazidime and PI-TZ. S. marcescens were sensitive to colistin, tigecycline and gentamycin.
Conclusions: The Gram-negative organisms E. coli, K.pneumoniae and P.aeruginosa were the most commonly isolated than GPCs with high mortality rates. Female gender, increasing age and longer duration of catheter in situ were risk factors for CaUTI in present study.
Key words: Bacteriology, Catheter-associated UTI, gram negative bacilli, gram positive cocci