International Journal of Health Sciences and Research

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Original Research Article

Year: 2018 | Month: October | Volume: 8 | Issue: 10 | Pages: 44-50

Clinicopathological Correlation in Granulomatous Lymphadenopathy With Emphasis on AFB Negative Cases- Role of FNAC as A Diagnostic Tool in A Tertiary Care Hospital in Industrial Belt of Haryana

Dr. Sujata Raychaudhuri1, Dr. Nimisha Sharma2, Dr. Mukta Pujani1, Dr. Mitasha Singh3, Dr Charu Agarwal2, Dr. Kanika Singh2, Dr Varsha Chauhan2, Dr. Aparna Khandelwal4

1Associate Professor, 2Assistant Professor, 4Senior Resident,
Dept. of Pathology, ESIC Medical College and Hospital, Faridabad
3Assistant Professor, Dept. of Community Medicine, ESIC Medical College and Hospital, Faridabad

Corresponding Author: Dr. Nimisha Sharma


Fine Needle Aspiration cytology (FNAC) is the first line, rapid diagnostic technique for the initial evaluation of superficial palpable swellings. Tuberculosis is the commonest cause of lymphadenopathy in India. Cytomorphology along with positive acid fast staining plays an important role in diagnosing these cases as tuberculous thus avoiding unnecessary surgeries. The aim is to study the clinicopathological parameters that may be of significance in diagnosing tuberculosis in granulomatous lymphadenopathies which are negative for AFB in Ziehl-Neelsen (ZN) staining in patients and their families who are insured under ESIC scheme in industrial belt of Haryana .This is a retrospective study and a total of 100 patients belonging to all age groups and both sexes, presenting with palpable lymph nodes in our institute over a period of 6 months with diagnosis of granulomatous, suppurative and necrotising lymphadenopathy on FNAC were included in the study. Those cases which were reactive or positive for malignancy were excluded. All the 100 Smears were subjected to Giemsa and Ziehl-Neelsen stain. Cases were categorised as AFB positive and AFB negative with granulomatous and necrotising pathologies and compared with different clinicopathological parameters. Data was entered in excel spread sheet and statistical analysis was done. P value <0.05 was taken to represent significant difference. The study concluded that the patients in 3rd decade with cervical lymphadenopathy having matted nodes or with size greater than 4 cm with blood mixed aspirate over a period of 15 days to 6 months were considered tuberculous although ZN stain for AFB was negative.

Key words: AFB negative, granulomatous, clinicopathological factors, tuberculosis.

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