Original Research Article
Year: 2017 | Month: Aug | Volume: 7 | Issue: 8 | Pages: 92-101
Score of Multi Parametric MRI: T2 and DWI to Assist Prostate Cancer Detection
Tjondro Setiawan1*, Bachtiar Murtala1**, Andi Fachruddin Benyamin2**, Mochammad Hatta3**, Ali Suyono Purwita4*, Taufan Tenggara4*, Egi Edward Manuputty4*, Gatot Susilo Lawrence5**
1Radiology Department, 2Internal Medicine Department, 3Microbiology Department,
4Urology Department, 5Pathology Anatomy Department,
*Gading Pluit Hospital-Jakarta,
Corresponding Author: Tjondro Setiawan
Purpose: The purpose of this study is to utilize simpler multi parametric Magnetic Resonance Imaging (mp-MRI): T2 Weighted Image (T2WI) and Diffusion Weighted Image (DWI) for prostate cancer detection without contrast injection.
Methods: This cross sectional study evaluated 19patients whom met inclusion and exclusion criteria. The prostate mp-MRI used pelvic phased array surface coil and endorectal coil. Category evaluation in T2WI and DWI sequence based on PIRADS version 2 standard, while ADC value as a complementary added value derived from DWI sequence by pointing the specified Region of Interest (ROI). The score and value results were analyzed statistically with Mann Whitney U test to know whether the results could differentiate prostate cancer with benign prostate. Cut off points were defined using Receiver Operating Curve (ROC).
Results: The mp-MRI median score for prostate cancer and benign prostate were 9 (8:10), 2 (2:9) respectively while ADC median value for prostate cancer and benign prostate were 0.542 (0.339:0.768), 0.987 (0.450:1.569). There was a significant difference between prostate cancer and benign prostate score (p=0.005, p<0.05), there was also a significant difference between ADC value for prostate cancer and benign prostate (p=0.022, p<0.05). Cut off point of 7 for mp-MRI score has 100% sensitivity and 71.4% specificity while ADC value cut off of 0.684 has 71.4% sensitivity and 91.7% specificity.
Conclusion: This simpler mp-MRI is able to differentiate prostate cancer from benign prostate. Using mp-MRI score cut off 7, it has good sensitivity also specificity and since it is simpler, it might be applicable and helpful for prostate cancer detection complemented by ADC value. Due to small sample number; therefore, further studies are needed to validate this research.
Key words:Prostate cancer - multi parametric MRI – ADC – non contrast – score