International Journal of Health Sciences and Research

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Short Communication

Year: 2017 | Month: July | Volume: 7 | Issue: 7 | Pages: 299-305

Effect of Intermittent Normobaric Hypoxia Training on Oxygen Tension in the Subcutaneous Tissue

Levashov Mikhail, Yanko Roman, Chaka Elena, Plotnikova Lidiia

Department of Clinical Physiology of Connective Tissue, A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine

Corresponding Author: Levashov Mikhail


It was investigated the dynamics of oxygen tension (PO2) in the subcutaneous tissue of male Wistar rats exposed to intermittent normobaric hypoxia (INH). Monitoring of the tissue PO2 was performed in situ using the open platinum electrode. It was evaluated the rate of change and the time to establish a relative steady state of tissue PO2 in the transitional stages of breathing: air – 10 % hypoxic gas mixture – air. Hypoxia was accompanied by cyclic changes in oxygen tension in the subcutaneous tissue of rats. When animals were transferring to breathe of hypoxic gas mixture, PO2 began to decrease already in the first seconds of observation. It was found that the time to reach the new relative steady state of PO2 in the rats' subcutaneous tissue after transition from air breathing to 10 % hypoxic gas mixture breathing ranged from 60 s to 360 s and after transition from hypoxic gas mixture breathing to air breathing – from 30 s to 240 s. We have noted an increase in tissue PO2 duration from 60 s to 390 s after period of hypoxia. For determining the optimum parameters of INH training it is necessary to take into account the phase nature of PO2 changing and the interindividual variations in setting time of PO2 steady state in the tissue after transition from air breathing to hypoxic gas mixture breathing and vice versa.

Key words: intermittent normobaric hypoxia, tissue oxygen tension

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