Original Research Article
Year: 2017 | Month: July | Volume: 7 | Issue: 7 | Pages: 80-85
Significance of 25 Hydroxy Vitamin D and Calcium in Pregnancy Induced Hypertension
Dr. Manpreet Kaur Dhillon1, Dr. Gurdeep Kaur Bedi2, Dr. Khushpreet Kaur3
1Senior Resident, Department of Biochemistry, Government Medical College, Patiala
2Professor, Department of Biochemistry, Government Medical College, Patiala
3Professor, Department of Obstetrics and Gynecology, Rajindra Hospital, Patiala
Corresponding Author: Dr. Manpreet Kaur Dhillon
Background: Pregnancy induced hypertension (PIH) is a common gestational disorder which complicates 7-10% of pregnancies globally and it is associated with maternal, fetal and neonatal morbidity and mortality. Yet the etiology of this disorder is little understood. Alterations in Vitamin D and serum calcium (Ca) levels have been suggested as effective factors in causing PIH.
Aim: To evaluate levels of 25 hydroxy vitamin D and calcium in pregnancy induced hypertension.
Materials And Methods: The study was conducted on 50 patients with pregnancy induced hypertension with 40 pre eclamptic women and 10 eclamptic women (study group) and 50 normal pregnant women (control group) in the Department of Biochemistry, Government Medical College Patiala. Sample was collected in plain vial. Serum 25-hydroxy vitamin D and calcium levels were evaluated by ELISA technique and OCPC colorimetric method respectively and the data obtained was statistically analysed.
Results: The Mean values of serum 25-hydroxyvitamin D levels in study group and control group were 9.83 ± 6.11 ng/ml and 14.92± 3.35 ng/ml respectively (Normal Value of vitamin D =30-74 ng/ml). The mean values of serum calcium in study group and control group were 8.76±1.12mg% and 9.48±0.93mg% respectively (normal value of calcium =8.5 to 10 mg%). The decrease in Vitamin D levels in study group as compared to control group shows statistically significant association (p value< 0.04). Similarly decrease in calcium levels among study group in comparison to control group shows statistically significant association (p<0.01).
Key words: Pregnancy induced hypertension, Pre eclampsia, Eclampsia, 25 Hydroxy Vitamin D, Serum Calcium