Original Research Article
Year: 2017 | Month: April | Volume: 7 | Issue: 4 | Pages: 176-182
Role of Cranberry Juice in Improving Symptoms of Recurrent UTI in Women of Reproductive Age Group
Dr Farzana Rizwan Arain
Associate professor, Obstetrics & Genecology Department, TAIF Medical College, TAIF, KSA
Objective: To evaluate the efficacy of cranberry juice in improving urinary symptoms in women presenting with recurrent Urinary Tract Infection (UTI).
Methods: This was an open label single arm study eligible study, participants satisfying the inclusion and exclusion criteria were enrolled in Department of Gynaecology, Muhammad Medical College (MMCH), Mirpurkhas, Sindh, Pakistan from March, 2011 to February, 2015. After satisfying the inclusion and exclusion criteria, the eligible participants were recruited in this prospective clinical trial. The clinical trial has two study periods; for a period of one year the recruited study participants were treated as usual (a Pre Cranberry juice period) and after a washout period of two weeks the study participants were prescribed cranberry juice and followed for a period of one year. The recurrence of UTI and organisms causing UTI was recorded for each episode of infection. For the present study ethical approval was granted by the institutional ethical review committee of Muhammad Medical College Hospital (MMCH), Pakistan. Written informed consent was obtained from all participants prior to recruitment. The data was analysed using SPSS version 21 (IBM, Chicago, IL).
Results: One hundred eligible women satisfying the inclusion and exclusion criteria were prescribed cranberry juice to use. There was significant difference in overall recurrence for Urinary Tract Infection during one year of follow up in the study population intervened with the Cranberry Juice was 30% compared to 50% when no Cranberry Juice was prescribed (p-value < 0.05). Thirty cultures confirmed recurrent UTI episodes were observed. Escherichia Coli was the most common causative organism for infection at enrolment (74%) and recurrence (83.5%). No serious adverse events occurred in the study participants during the course of the trial.
Conclusion: Among healthy sexually active women intake of Cranberry Juice has been found effective in reducing the incidence of recurrent UTI at 1 year follow up.
Key words: Cranberry Juice, Escherichia Coli, Recurrence, Urinary Tract Infection